{"title":"N-Hydroxysuccinimide (NHS) PEGs","description":"\u003cp\u003ePolysciences’ NHS-PEGs are polyethylene glycol derivatives functionalized with N-hydroxysuccinimide (NHS) ester groups (at one or both ends), enabling rapid, stable amide bond formation with primary amines in proteins, peptides, or material surfaces. These activated PEGs are available in structures such as PEG di(NHS), methoxy PEG NHS, Boc-Amine PEG NHS, and biotin-PEG-NHS, across multiple molecular weights, making them suited for crosslinking, PEGylation, labeling, and surface modification applications. (Sources: PEG Di(NHS), Mp 20000; Methoxy PEG NHS, Mp 750; Boc-Amine PEG NHS, Mp 3000; Biotin PEG NHS, Mp 5000.\u003c\/p\u003e","products":[{"product_id":"methoxy-peg-nhs-mp-750","title":"Methoxy PEG NHS, Mp 750","description":"\u003cp\u003eMethoxy PEG NHS (mPEG-NHS) is a PEG derivative with an N-hydroxysuccinimide (NHS) ester group, designed for amide bond formation with primary amines in proteins, peptides, and biomaterials. This highly reactive ester enables stable PEGylation, surface functionalization, and hydrogel formation while retaining PEG’s water solubility and biocompatibility.\u003c\/p\u003e\n\n\u003cp\u003eApplications:\n\u003cbr\u003eProtein \u0026amp; Antibody PEGylation: Reacts with lysine residues, enhancing stability, circulation half-life, and bioavailability of biologics.\n\u003cbr\u003eHydrogel \u0026amp; Polymer Crosslinking: Forms covalent amide bonds with amine-functionalized polymers, improving biocompatibility.\n\u003cbr\u003eSurface Modification: PEG-coats medical implants, biosensors, and nanoparticles, reducing non-specific binding and immune response.\n\u003cbr\u003eTargeted Drug Delivery: Stabilizes drug carriers and enhances therapeutic efficacy of biologics.\u003c\/p\u003e","brand":"Polysciences","offers":[{"title":"26064-1 (1 g)","offer_id":46425789104342,"sku":"26064-1","price":309.0,"currency_code":"USD","in_stock":true},{"title":"26064-5 (5 g)","offer_id":46425789137110,"sku":"26064-5","price":927.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0713\/5258\/2358\/files\/NEW_methoxy__nhs_f85409c8-2c86-4e09-9fa3-4ffbbd9c62d9.png?v=1738252679"},{"product_id":"methoxy-peg-nhs-mp-2000","title":"Methoxy PEG NHS, Mp 2000","description":"\u003cp\u003eMethoxy PEG NHS (mPEG-NHS) is a PEG derivative with an N-hydroxysuccinimide (NHS) ester group, designed for amide bond formation with primary amines in proteins, peptides, and biomaterials. This highly reactive ester enables stable PEGylation, surface functionalization, and hydrogel formation while retaining PEG’s water solubility and biocompatibility.\u003c\/p\u003e\n\n\u003cp\u003eApplications:\n\u003cbr\u003eProtein \u0026amp; Antibody PEGylation: Reacts with lysine residues, enhancing stability, circulation half-life, and bioavailability of biologics.\n\u003cbr\u003eHydrogel \u0026amp; Polymer Crosslinking: Forms covalent amide bonds with amine-functionalized polymers, improving biocompatibility.\n\u003cbr\u003eSurface Modification: PEG-coats medical implants, biosensors, and nanoparticles, reducing non-specific binding and immune response.\n\u003cbr\u003eTargeted Drug Delivery: Stabilizes drug carriers and enhances therapeutic efficacy of biologics.\u003c\/p\u003e","brand":"Polysciences","offers":[{"title":"26065-1 (1 g)","offer_id":46425789202646,"sku":"26065-1","price":303.0,"currency_code":"USD","in_stock":true},{"title":"26065-5 (5 g)","offer_id":46425789235414,"sku":"26065-5","price":927.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0713\/5258\/2358\/files\/NEW_methoxy__nhs_1_7c2b95a6-7311-436c-bed0-a06bc8e45e6d.png?v=1738252680"},{"product_id":"methoxy-peg-nhs-mp-5000","title":"Methoxy PEG NHS, Mp 5000","description":"\u003cp\u003eMethoxy PEG NHS (mPEG-NHS) is a PEG derivative with an N-hydroxysuccinimide (NHS) ester group, designed for amide bond formation with primary amines in proteins, peptides, and biomaterials. This highly reactive ester enables stable PEGylation, surface functionalization, and hydrogel formation while retaining PEG’s water solubility and biocompatibility.\u003c\/p\u003e\n\n\u003cp\u003eApplications:\n\u003cbr\u003eProtein \u0026amp; Antibody PEGylation: Reacts with lysine residues, enhancing stability, circulation half-life, and bioavailability of biologics.\n\u003cbr\u003eHydrogel \u0026amp; Polymer Crosslinking: Forms covalent amide bonds with amine-functionalized polymers, improving biocompatibility.\n\u003cbr\u003eSurface Modification: PEG-coats medical implants, biosensors, and nanoparticles, reducing non-specific binding and immune response.\n\u003cbr\u003eTargeted Drug Delivery: Stabilizes drug carriers and enhances therapeutic efficacy of biologics.\u003c\/p\u003e","brand":"Polysciences","offers":[{"title":"26066-1 (1 g)","offer_id":46425789366486,"sku":"26066-1","price":255.0,"currency_code":"USD","in_stock":true},{"title":"26066-5 (5 g)","offer_id":46425789399254,"sku":"26066-5","price":927.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0713\/5258\/2358\/files\/NEW_methoxy__nhs_1_2_6cb6c020-11f4-44a9-b844-d526b618abd7.png?v=1738252679"},{"product_id":"methoxy-peg-nhs-mp-10000","title":"Methoxy PEG NHS, Mp 10000","description":"\u003cp\u003eMethoxy PEG NHS (mPEG-NHS) is a PEG derivative with an N-hydroxysuccinimide (NHS) ester group, designed for amide bond formation with primary amines in proteins, peptides, and biomaterials. This highly reactive ester enables stable PEGylation, surface functionalization, and hydrogel formation while retaining PEG’s water solubility and biocompatibility.\u003c\/p\u003e\n\n\u003cp\u003eApplications:\n\u003cbr\u003eProtein \u0026amp; Antibody PEGylation: Reacts with lysine residues, enhancing stability, circulation half-life, and bioavailability of biologics.\n\u003cbr\u003eHydrogel \u0026amp; Polymer Crosslinking: Forms covalent amide bonds with amine-functionalized polymers, improving biocompatibility.\n\u003cbr\u003eSurface Modification: PEG-coats medical implants, biosensors, and nanoparticles, reducing non-specific binding and immune response.\n\u003cbr\u003eTargeted Drug Delivery: Stabilizes drug carriers and enhances therapeutic efficacy of biologics.\u003c\/p\u003e","brand":"Polysciences","offers":[{"title":"26067-1 (1 g)","offer_id":46425789530326,"sku":"26067-1","price":360.5,"currency_code":"USD","in_stock":true},{"title":"26067-5 (5 g)","offer_id":46425789563094,"sku":"26067-5","price":927.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0713\/5258\/2358\/files\/NEW_methoxy__nhs_1_2_1_e3f9e825-3f17-4417-b165-cf430c4c511b.png?v=1738252679"},{"product_id":"methoxy-peg-nhs-mp-20000","title":"Methoxy PEG NHS, Mp 20000","description":"\u003cp\u003eMethoxy PEG NHS (mPEG-NHS) is a PEG derivative with an N-hydroxysuccinimide (NHS) ester group, designed for amide bond formation with primary amines in proteins, peptides, and biomaterials. This highly reactive ester enables stable PEGylation, surface functionalization, and hydrogel formation while retaining PEG’s water solubility and biocompatibility.\u003c\/p\u003e\n\n\u003cp\u003eApplications:\n\u003cbr\u003eProtein \u0026amp; Antibody PEGylation: Reacts with lysine residues, enhancing stability, circulation half-life, and bioavailability of biologics.\n\u003cbr\u003eHydrogel \u0026amp; Polymer Crosslinking: Forms covalent amide bonds with amine-functionalized polymers, improving biocompatibility.\n\u003cbr\u003eSurface Modification: PEG-coats medical implants, biosensors, and nanoparticles, reducing non-specific binding and immune response.\n\u003cbr\u003eTargeted Drug Delivery: Stabilizes drug carriers and enhances therapeutic efficacy of biologics.\u003c\/p\u003e","brand":"Polysciences","offers":[{"title":"26068-1 (1 g)","offer_id":46425789595862,"sku":"26068-1","price":306.0,"currency_code":"USD","in_stock":true},{"title":"26068-5 (5 g)","offer_id":46425789628630,"sku":"26068-5","price":927.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0713\/5258\/2358\/files\/NEW_methoxy__nhs_1_2_1_1_574266fd-d03e-4511-8a81-5837c92f2597.png?v=1738252679"},{"product_id":"peg-dinhs-mp-2000","title":"PEG di(NHS), Mp 2000","description":"\u003cp\u003ePEG Di(NHS) (NHS-PEG-NHS) is a bifunctional PEG derivative with N-hydroxysuccinimide (NHS) ester groups on both termini, designed for amide bond formation with primary amines. This highly reactive structure enables efficient crosslinking of proteins, peptides, and biomaterials, making it useful for bioconjugation, hydrogel formation, and surface modification.\u003c\/p\u003e\n\n\u003cp\u003eApplications:\n\u003cbr\u003eProtein Crosslinking \u0026amp; PEGylation: Forms amide bonds with lysine residues, enhancing solubility and stability of biomolecules.\n\u003cbr\u003eHydrogel \u0026amp; Polymer Synthesis: Crosslinks amine-functionalized polymers, improving mechanical properties and biocompatibility.\n\u003cbr\u003eSurface Coating \u0026amp; Biocompatibility: Reduces fouling on biosensors, implants, and nanoparticles.\n\u003cbr\u003eDrug Delivery \u0026amp; Targeted Therapy: Functionalizes drug carriers for enhanced therapeutic performance.\u003c\/p\u003e","brand":"Polysciences","offers":[{"title":"26113-1 (1 g)","offer_id":46425793364182,"sku":"26113-1","price":285.6,"currency_code":"USD","in_stock":true},{"title":"26113-5 (5 g)","offer_id":46425793396950,"sku":"26113-5","price":927.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0713\/5258\/2358\/files\/NEW_dinhs_14044284-f0f5-4632-8e30-59472338f4ee.png?v=1738252678"},{"product_id":"peg-dinhs-mp-3000","title":"PEG di(NHS), Mp 3000","description":"\u003c!-- PDP Content: PEG di(NHS), Mp ~3000 (26114) --\u003e\n\u003cstyle\u003e\n  \/* ===== Base layout (compact spacing, Shopify-friendly) ===== *\/\n  .pdp-content { line-height: 1.55; }\n\n  .pdp-content h2{\n    font-size: 1.35rem;\n    font-weight: 700;\n    margin: 0.9rem 0 0.4rem;\n  }\n\n  .pdp-content h3{\n    font-size: 1.1rem;\n    font-weight: 700;\n    margin: 0.7rem 0 0.35rem;\n  }\n\n  .pdp-content p{ margin: 0 0 0.45rem; }\n\n  .pdp-content ul{\n    margin: 0.3rem 0 0.6rem;\n    padding-left: 1.1rem;\n    list-style: disc;\n  }\n\n  .pdp-content li{ margin: 0.25rem 0; }\n\n  .pdp-divider{\n    border: 0;\n    border-top: 1px solid rgba(0,0,0,0.15);\n    margin: 0.6rem 0 0.4rem;\n  }\n\n  \/* ===== FAQ Section ===== *\/\n  .pdp-faq h2{\n    font-size: 1.35rem;\n    font-weight: 700;\n    margin: 0 0 0.35rem;\n  }\n\n  .pdp-faq .faq-intro{\n    margin: 0 0 0.55rem;\n    line-height: 1.5;\n    color: #333;\n  }\n\n  .pdp-faq ul{\n    margin: 0;\n    padding-left: 1.1rem;\n    list-style: disc;\n  }\n\n  .pdp-faq li{ margin-bottom: 0.55rem; }\n\n  .pdp-faq summary{\n    cursor: pointer;\n    font-weight: 600;\n    line-height: 1.4;\n    list-style: none;\n    display: list-item;\n  }\n\n  .pdp-faq summary::-webkit-details-marker{ display: none; }\n\n  .pdp-faq details[open] summary{ margin-bottom: 0.25rem; }\n\n  .pdp-faq .answer{\n    margin-left: 1.1rem;\n    line-height: 1.55;\n    font-size: 0.97rem;\n  }\n\n  .pdp-faq .answer p{ margin: 0.3rem 0 0.45rem; }\n\n  @media (max-width: 480px){\n    .pdp-content h2,\n    .pdp-faq h2{ font-size: 1.25rem; }\n    .pdp-faq .answer{ margin-left: 0.9rem; }\n  }\n\u003c\/style\u003e\n\n\u003csection class=\"pdp-content\" aria-label=\"Product information\"\u003e\n\n  \u003ch2\u003ePEG di(NHS), Mp ~3000 (26114)\u003c\/h2\u003e\n\n  \u003cp\u003e\n    PEG di(NHS) (NHS-PEG-NHS) is a bifunctional polyethylene glycol derivative\n    bearing \u003cstrong\u003eN-hydroxysuccinimide (NHS) ester groups\u003c\/strong\u003e on both termini.\n    These activated esters are designed for efficient \u003cstrong\u003eamide bond formation\n    with primary amines\u003c\/strong\u003e under mild reaction conditions.\n  \u003c\/p\u003e\n\n  \u003cp\u003e\n    With an average molecular weight of approximately \u003cstrong\u003e3,000 Da\u003c\/strong\u003e,\n    this homobifunctional PEG linker provides a relatively short, flexible spacer\n    that enables controlled crosslinking and conjugation of amine-containing\n    biomolecules. PEG di(NHS), Mp ~3000 is commonly used in bioconjugation,\n    hydrogel synthesis, and surface functionalization where closer spacing between\n    linked components is desired.\n  \u003c\/p\u003e\n\n  \u003chr class=\"pdp-divider\"\u003e\n\n  \u003ch3\u003eKey Characteristics\u003c\/h3\u003e\n  \u003cul\u003e\n    \u003cli\u003e\n\u003cstrong\u003ePEG backbone:\u003c\/strong\u003e Hydrophilic spacer that improves solubility and compatibility in aqueous systems\u003c\/li\u003e\n    \u003cli\u003e\n\u003cstrong\u003eReactive groups:\u003c\/strong\u003e NHS esters for selective reaction with primary amines\u003c\/li\u003e\n    \u003cli\u003e\n\u003cstrong\u003eFunctionality:\u003c\/strong\u003e Homobifunctional (NHS groups on both ends)\u003c\/li\u003e\n    \u003cli\u003e\n\u003cstrong\u003eAverage molecular weight:\u003c\/strong\u003e Mp ~3,000\u003c\/li\u003e\n  \u003c\/ul\u003e\n\n  \u003chr class=\"pdp-divider\"\u003e\n\n  \u003ch3\u003eTypical Applications\u003c\/h3\u003e\n  \u003cul\u003e\n    \u003cli\u003e\n      \u003cstrong\u003eProtein crosslinking \u0026amp; PEGylation:\u003c\/strong\u003e\n      Forms stable amide bonds with lysine residues to modify proteins and peptides,\n      enhancing solubility and stability.\n    \u003c\/li\u003e\n    \u003cli\u003e\n      \u003cstrong\u003eHydrogel \u0026amp; polymer synthesis:\u003c\/strong\u003e\n      Crosslinks amine-functional polymers to generate PEG-based networks with\n      tunable mechanical properties.\n    \u003c\/li\u003e\n    \u003cli\u003e\n      \u003cstrong\u003eSurface coating \u0026amp; biocompatibility:\u003c\/strong\u003e\n      Enables PEGylation of surfaces, nanoparticles, and biosensors to reduce\n      nonspecific adsorption.\n    \u003c\/li\u003e\n    \u003cli\u003e\n      \u003cstrong\u003eDrug delivery research:\u003c\/strong\u003e\n      Functionalizes carriers and scaffolds where shorter PEG spacing is beneficial\n      for controlled interactions.\n    \u003c\/li\u003e\n  \u003c\/ul\u003e\n\n  \u003c!-- FAQs --\u003e\n  \u003csection class=\"pdp-faq\" aria-labelledby=\"pdp-faq-title\"\u003e\n    \u003chr class=\"pdp-divider\"\u003e\n    \u003ch2 id=\"pdp-faq-title\"\u003eFAQs\u003c\/h2\u003e\n    \u003cp class=\"faq-intro\"\u003e\n      Common questions about \u003cstrong\u003ePEG di(NHS), Mp ~3000\u003c\/strong\u003e.\n    \u003c\/p\u003e\n\n    \u003cul\u003e\n      \u003cli\u003e\n        \u003cdetails\u003e\n          \u003csummary\u003eWhat is the advantage of a PEG linker with Mp ~3000?\u003c\/summary\u003e\n          \u003cdiv class=\"answer\"\u003e\n            \u003cp\u003e\n              A PEG of approximately 3,000 Da provides a shorter spacer length,\n              allowing closer proximity between conjugated molecules while still\n              maintaining PEG-associated hydrophilicity.\n            \u003c\/p\u003e\n          \u003c\/div\u003e\n        \u003c\/details\u003e\n      \u003c\/li\u003e\n\n      \u003cli\u003e\n        \u003cdetails\u003e\n          \u003csummary\u003eWhich functional groups react with NHS esters?\u003c\/summary\u003e\n          \u003cdiv class=\"answer\"\u003e\n            \u003cp\u003e\n              NHS esters react primarily with primary amines, such as those found on\n              lysine residues in proteins or amine-terminated polymers.\n            \u003c\/p\u003e\n          \u003c\/div\u003e\n        \u003c\/details\u003e\n      \u003c\/li\u003e\n\n      \u003cli\u003e\n        \u003cdetails\u003e\n          \u003csummary\u003eIs this material intended for clinical or GMP use?\u003c\/summary\u003e\n          \u003cdiv class=\"answer\"\u003e\n            \u003cp\u003e\n              PEG di(NHS) is typically supplied for research and development use.\n              Suitability for regulated or clinical applications should be evaluated\n              by the end user.\n            \u003c\/p\u003e\n          \u003c\/div\u003e\n        \u003c\/details\u003e\n      \u003c\/li\u003e\n    \u003c\/ul\u003e\n  \u003c\/section\u003e\n\n\u003c\/section\u003e\n","brand":"Polysciences","offers":[{"title":"26114-1 (1 g)","offer_id":46425793429718,"sku":"26114-1","price":410.69,"currency_code":"USD","in_stock":true},{"title":"26114-5 (5 g)","offer_id":46425793462486,"sku":"26114-5","price":927.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0713\/5258\/2358\/files\/NEW_dinhs_1_3e9c9721-c6b3-46f2-b7ca-542750973b10.png?v=1738252678"},{"product_id":"peg-dinhs-mp-6000","title":"PEG di(NHS), Mp 6000","description":"\u003c!-- PDP Content: PEG di(NHS), Mp ~6000 (26115) --\u003e\n\u003cstyle\u003e\n  \/* ===== Base layout (compact spacing, Shopify-friendly) ===== *\/\n  .pdp-content { line-height: 1.55; }\n\n  .pdp-content h2{\n    font-size: 1.35rem;\n    font-weight: 700;\n    margin: 0.9rem 0 0.4rem;\n  }\n\n  .pdp-content h3{\n    font-size: 1.1rem;\n    font-weight: 700;\n    margin: 0.7rem 0 0.35rem;\n  }\n\n  .pdp-content p{ margin: 0 0 0.45rem; }\n\n  .pdp-content ul{\n    margin: 0.3rem 0 0.6rem;\n    padding-left: 1.1rem;\n    list-style: disc;\n  }\n\n  .pdp-content li{ margin: 0.25rem 0; }\n\n  .pdp-divider{\n    border: 0;\n    border-top: 1px solid rgba(0,0,0,0.15);\n    margin: 0.6rem 0 0.4rem;\n  }\n\n  \/* ===== FAQ Section ===== *\/\n  .pdp-faq h2{\n    font-size: 1.35rem;\n    font-weight: 700;\n    margin: 0 0 0.35rem;\n  }\n\n  .pdp-faq .faq-intro{\n    margin: 0 0 0.55rem;\n    line-height: 1.5;\n    color: #333;\n  }\n\n  .pdp-faq ul{\n    margin: 0;\n    padding-left: 1.1rem;\n    list-style: disc;\n  }\n\n  .pdp-faq li{ margin-bottom: 0.55rem; }\n\n  .pdp-faq summary{\n    cursor: pointer;\n    font-weight: 600;\n    line-height: 1.4;\n    list-style: none;\n    display: list-item;\n  }\n\n  .pdp-faq summary::-webkit-details-marker{ display: none; }\n\n  .pdp-faq details[open] summary{ margin-bottom: 0.25rem; }\n\n  .pdp-faq .answer{\n    margin-left: 1.1rem;\n    line-height: 1.55;\n    font-size: 0.97rem;\n  }\n\n  .pdp-faq .answer p{ margin: 0.3rem 0 0.45rem; }\n\n  @media (max-width: 480px){\n    .pdp-content h2,\n    .pdp-faq h2{ font-size: 1.25rem; }\n    .pdp-faq .answer{ margin-left: 0.9rem; }\n  }\n\u003c\/style\u003e\n\u003csection class=\"pdp-content\" aria-label=\"Product information\"\u003e\n\u003ch2\u003ePEG di(NHS), Mp ~6000 (26115)\u003c\/h2\u003e\n\u003cp\u003ePEG di(NHS) (NHS-PEG-NHS) is a bifunctional polyethylene glycol derivative functionalized with \u003cstrong\u003eN-hydroxysuccinimide (NHS) ester groups\u003c\/strong\u003e on both termini. These activated esters are designed to react efficiently with \u003cstrong\u003eprimary amines\u003c\/strong\u003e, forming stable amide bonds under mild conditions.\u003c\/p\u003e\n\u003cp\u003eWith an average molecular weight of approximately \u003cstrong\u003e6,000 Da\u003c\/strong\u003e, this homobifunctional PEG linker enables controlled crosslinking and spacing between amine-containing molecules. PEG di(NHS) is widely used in bioconjugation, hydrogel formation, and surface modification where predictable reactivity and PEG-mediated hydrophilicity are desired.\u003c\/p\u003e\n\u003chr class=\"pdp-divider\"\u003e\n\u003ch3\u003eKey Properties\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePEG backbone:\u003c\/strong\u003e Hydrophilic, flexible spacer that improves solubility and biocompatibility\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReactive groups:\u003c\/strong\u003e NHS esters for efficient amide bond formation with primary amines\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFunctionality:\u003c\/strong\u003e Homobifunctional (NHS on both termini)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAverage molecular weight:\u003c\/strong\u003e Mp ~6,000\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr class=\"pdp-divider\"\u003e\n\u003ch3\u003eApplications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eProtein crosslinking \u0026amp; PEGylation:\u003c\/strong\u003e Forms amide bonds with lysine residues to enhance solubility, stability, and circulation behavior of biomolecules.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHydrogel \u0026amp; polymer synthesis:\u003c\/strong\u003e Crosslinks amine-functional polymers and biomacromolecules to form well-defined PEG-based networks.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSurface modification \u0026amp; antifouling coatings:\u003c\/strong\u003e Introduces PEG layers on surfaces, nanoparticles, and biosensors to reduce nonspecific adsorption.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDrug delivery research:\u003c\/strong\u003e Functionalizes carriers and scaffolds for improved dispersion and performance in experimental delivery systems.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c!-- FAQs --\u003e\n\u003csection class=\"pdp-faq\" aria-labelledby=\"pdp-faq-title\"\u003e\u003chr class=\"pdp-divider\"\u003e\n\u003ch2 id=\"pdp-faq-title\"\u003eFAQs\u003c\/h2\u003e\n\u003cp class=\"faq-intro\"\u003eCommon questions about \u003cstrong\u003ePEG di(NHS), Mp ~6000\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cdetails\u003e\n\u003csummary\u003eWhat does “di(NHS)” mean?\u003c\/summary\u003e\n\u003cdiv class=\"answer\"\u003e\n\u003cp\u003e“di(NHS)” indicates that the PEG molecule is functionalized with NHS ester groups on both ends, making it homobifunctional and suitable for crosslinking two amine-containing species.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdetails\u003e\n\u003csummary\u003eWhat types of groups react with NHS esters?\u003c\/summary\u003e\n\u003cdiv class=\"answer\"\u003e\n\u003cp\u003eNHS esters primarily react with primary amines, such as those found on lysine residues of proteins or amine-functional polymers, to form stable amide bonds.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdetails\u003e\n\u003csummary\u003eWhy use a PEG linker with Mp ~6000?\u003c\/summary\u003e\n\u003cdiv class=\"answer\"\u003e\n\u003cp\u003eA PEG of approximately 6,000 Da provides a balance between flexibility, spacing, and solubility, allowing controlled separation between conjugated components without excessive steric bulk.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdetails\u003e\n\u003csummary\u003eIs PEG di(NHS) suitable for regulated or clinical use?\u003c\/summary\u003e\n\u003cdiv class=\"answer\"\u003e\n\u003cp\u003ePEG di(NHS) is typically supplied for research and development use. Users should assess suitability for their specific application and regulatory requirements.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/section\u003e\n\u003c\/section\u003e","brand":"Polysciences","offers":[{"title":"26115-1 (1 g)","offer_id":46425793528022,"sku":"26115-1","price":309.0,"currency_code":"USD","in_stock":true},{"title":"26115-5 (5 g)","offer_id":46425793560790,"sku":"26115-5","price":927.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0713\/5258\/2358\/files\/NEW_dinhs_1_1_9b2ef5dc-e55e-4665-94ae-52abce25ddd9.png?v=1738252678"},{"product_id":"peg-dinhs-mp-10000","title":"PEG di(NHS), Mp 10000","description":"\u003cp\u003ePEG Di(NHS) (NHS-PEG-NHS) is a bifunctional PEG derivative with N-hydroxysuccinimide (NHS) ester groups on both termini, designed for amide bond formation with primary amines. This highly reactive structure enables efficient crosslinking of proteins, peptides, and biomaterials, making it useful for bioconjugation, hydrogel formation, and surface modification.\u003c\/p\u003e\n\n\u003cp\u003eApplications:\n\u003cbr\u003eProtein Crosslinking \u0026amp; PEGylation: Forms amide bonds with lysine residues, enhancing solubility and stability of biomolecules.\n\u003cbr\u003eHydrogel \u0026amp; Polymer Synthesis: Crosslinks amine-functionalized polymers, improving mechanical properties and biocompatibility.\n\u003cbr\u003eSurface Coating \u0026amp; Biocompatibility: Reduces fouling on biosensors, implants, and nanoparticles.\n\u003cbr\u003eDrug Delivery \u0026amp; Targeted Therapy: Functionalizes drug carriers for enhanced therapeutic performance.\u003c\/p\u003e","brand":"Polysciences","offers":[{"title":"26116-1 (1 g)","offer_id":46425793659094,"sku":"26116-1","price":410.69,"currency_code":"USD","in_stock":true},{"title":"26116-5 (5 g)","offer_id":46425793691862,"sku":"26116-5","price":927.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0713\/5258\/2358\/files\/NEW_dinhs_1_1_1_57c29963-22e3-4a66-867b-bd97134f3c55.png?v=1738252679"},{"product_id":"peg-dinhs-mp-20000","title":"PEG di(NHS), Mp 20000","description":"\u003cp\u003ePEG Di(NHS) (NHS-PEG-NHS) is a bifunctional PEG derivative with N-hydroxysuccinimide (NHS) ester groups on both termini, designed for amide bond formation with primary amines. This highly reactive structure enables efficient crosslinking of proteins, peptides, and biomaterials, making it useful for bioconjugation, hydrogel formation, and surface modification.\u003c\/p\u003e\n\n\u003cp\u003eApplications:\n\u003cbr\u003eProtein Crosslinking \u0026amp; PEGylation: Forms amide bonds with lysine residues, enhancing solubility and stability of biomolecules.\n\u003cbr\u003eHydrogel \u0026amp; Polymer Synthesis: Crosslinks amine-functionalized polymers, improving mechanical properties and biocompatibility.\n\u003cbr\u003eSurface Coating \u0026amp; Biocompatibility: Reduces fouling on biosensors, implants, and nanoparticles.\n\u003cbr\u003eDrug Delivery \u0026amp; Targeted Therapy: Functionalizes drug carriers for enhanced therapeutic performance.\u003c\/p\u003e","brand":"Polysciences","offers":[{"title":"26117-1 (1 g)","offer_id":46425793790166,"sku":"26117-1","price":410.69,"currency_code":"USD","in_stock":true},{"title":"26117-5 (5 g)","offer_id":46425793822934,"sku":"26117-5","price":927.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0713\/5258\/2358\/files\/NEW_dinhs_1_1_1_1_228c2c2c-0166-438b-ab4b-6a712d7c897d.png?v=1738252678"},{"product_id":"nhs-peg-alkyne-mp-3000","title":"NHS PEG alkyne, Mp 3000","description":"\u003cp\u003eNHS PEG Alkyne (NHS-PEG-Alkyne) is a bifunctional PEG reagent containing an N-hydroxysuccinimide (NHS) ester and a terminal alkyne (-C≡CH). The NHS group reacts with primary amines, forming stable amide bonds, while the alkyne moiety enables CuAAC click reactions with azide-functionalized biomolecules. This dual functionality makes it ideal for bio-orthogonal labeling, PEGylation, and hydrogel crosslinking.\u003c\/p\u003e\n\n\u003cp\u003eApplications:\n\u003cbr\u003eBio-orthogonal Chemistry \u0026amp; Click Reactions: Facilitates azide-alkyne cycloaddition for site-specific labeling.\n\u003cbr\u003eProtein \u0026amp; Antibody Conjugation: Covalently links amine-functionalized biomolecules for drug delivery applications.\n\u003cbr\u003eHydrogel Crosslinking: Forms biocompatible, PEG-based networks with precise control over mechanical properties.\n\u003cbr\u003eSurface Functionalization: Enhances biocompatibility of medical coatings, biosensors, and nanoparticles.\u003c\/p\u003e","brand":"Polysciences","offers":[{"title":"26127-100 (100 mg)","offer_id":46425794805974,"sku":"26127-100","price":299.17,"currency_code":"USD","in_stock":true},{"title":"26127-500 (500 mg)","offer_id":46425794838742,"sku":"26127-500","price":1072.57,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0713\/5258\/2358\/files\/NEW_26127_ae07a680-e09b-4ffe-bc85-fe2aef3955df.png?v=1738252678"},{"product_id":"nhs-peg-alkyne-mp-5000","title":"NHS PEG alkyne, Mp 5000","description":"\u003cp\u003eNHS PEG Alkyne (NHS-PEG-Alkyne) is a bifunctional PEG reagent containing an N-hydroxysuccinimide (NHS) ester and a terminal alkyne (-C≡CH). The NHS group reacts with primary amines, forming stable amide bonds, while the alkyne moiety enables CuAAC click reactions with azide-functionalized biomolecules. This dual functionality makes it ideal for bio-orthogonal labeling, PEGylation, and hydrogel crosslinking.\u003c\/p\u003e\n\n\u003cp\u003eApplications:\n\u003cbr\u003eBio-orthogonal Chemistry \u0026amp; Click Reactions: Facilitates azide-alkyne cycloaddition for site-specific labeling.\n\u003cbr\u003eProtein \u0026amp; Antibody Conjugation: Covalently links amine-functionalized biomolecules for drug delivery applications.\n\u003cbr\u003eHydrogel Crosslinking: Forms biocompatible, PEG-based networks with precise control over mechanical properties.\n\u003cbr\u003eSurface Functionalization: Enhances biocompatibility of medical coatings, biosensors, and nanoparticles.\u003c\/p\u003e","brand":"Polysciences","offers":[{"title":"26128-100 (100 mg)","offer_id":46425794904278,"sku":"26128-100","price":312.97,"currency_code":"USD","in_stock":true},{"title":"26128-500 (500 mg)","offer_id":46425794937046,"sku":"26128-500","price":1072.57,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0713\/5258\/2358\/files\/NEW_26127_1_e4489345-cf1b-41fd-a642-2928bd965ea9.png?v=1738252678"},{"product_id":"nhs-peg-alkyne-mp-10000","title":"NHS PEG alkyne, Mp 10000","description":"\u003cp\u003eNHS PEG Alkyne (NHS-PEG-Alkyne) is a bifunctional PEG reagent containing an N-hydroxysuccinimide (NHS) ester and a terminal alkyne (-C≡CH). The NHS group reacts with primary amines, forming stable amide bonds, while the alkyne moiety enables CuAAC click reactions with azide-functionalized biomolecules. This dual functionality makes it ideal for bio-orthogonal labeling, PEGylation, and hydrogel crosslinking.\u003c\/p\u003e\n\n\u003cp\u003eApplications:\n\u003cbr\u003eBio-orthogonal Chemistry \u0026amp; Click Reactions: Facilitates azide-alkyne cycloaddition for site-specific labeling.\n\u003cbr\u003eProtein \u0026amp; Antibody Conjugation: Covalently links amine-functionalized biomolecules for drug delivery applications.\n\u003cbr\u003eHydrogel Crosslinking: Forms biocompatible, PEG-based networks with precise control over mechanical properties.\n\u003cbr\u003eSurface Functionalization: Enhances biocompatibility of medical coatings, biosensors, and nanoparticles.\u003c\/p\u003e","brand":"Polysciences","offers":[{"title":"26129-100 (100 mg)","offer_id":46425795068118,"sku":"26129-100","price":309.93,"currency_code":"USD","in_stock":true},{"title":"26129-500 (500 mg)","offer_id":46425795100886,"sku":"26129-500","price":1072.57,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0713\/5258\/2358\/files\/NEW_26127_1_1_ed08231f-1a5c-44c6-ade4-4d7c770afa4d.png?v=1738252678"},{"product_id":"nhs-peg-alkyne-mp-20000","title":"NHS PEG alkyne, Mp 20000","description":"\u003cp\u003eNHS PEG Alkyne (NHS-PEG-Alkyne) is a bifunctional PEG reagent containing an N-hydroxysuccinimide (NHS) ester and a terminal alkyne (-C≡CH). The NHS group reacts with primary amines, forming stable amide bonds, while the alkyne moiety enables CuAAC click reactions with azide-functionalized biomolecules. This dual functionality makes it ideal for bio-orthogonal labeling, PEGylation, and hydrogel crosslinking.\u003c\/p\u003e\n\n\u003cp\u003eApplications:\n\u003cbr\u003eBio-orthogonal Chemistry \u0026amp; Click Reactions: Facilitates azide-alkyne cycloaddition for site-specific labeling.\n\u003cbr\u003eProtein \u0026amp; Antibody Conjugation: Covalently links amine-functionalized biomolecules for drug delivery applications.\n\u003cbr\u003eHydrogel Crosslinking: Forms biocompatible, PEG-based networks with precise control over mechanical properties.\n\u003cbr\u003eSurface Functionalization: Enhances biocompatibility of medical coatings, biosensors, and nanoparticles.\u003c\/p\u003e","brand":"Polysciences","offers":[{"title":"26130-100 (100 mg)","offer_id":46425795166422,"sku":"26130-100","price":294.93,"currency_code":"USD","in_stock":true},{"title":"26130-500 (500 mg)","offer_id":46425795199190,"sku":"26130-500","price":1072.57,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0713\/5258\/2358\/files\/NEW_26127_1_1_1_3a45c664-67af-4259-85a7-bbfd55215f66.png?v=1738252678"},{"product_id":"peg-diamine-mp-5000","title":"Biotin PEG NHS, Mp 3000","description":"\u003cp\u003eBiotin PEG NHS is an activated biotinylated PEG linker that contains an N-hydroxysuccinimide (NHS) ester for rapid conjugation to primary amines on biomolecules such as proteins, antibodies, and peptides. The NHS ester enables efficient and stable amide bond formation under mild conditions, while the PEG spacer enhances solubility, reduces aggregation, and minimizes steric hindrance in biotin-avidin interactions.\n\u003cbr\u003eApplications:\n\u003cbr\u003eProtein \u0026amp; Antibody Labeling: Facilitates rapid biotinylation of biomolecules for affinity purification and assay development.\n\u003cbr\u003eNanoparticle \u0026amp; Surface Functionalization: Enhances stability and specificity in biosensor platforms.\n\u003cbr\u003eDrug Delivery \u0026amp; Targeting: Used in targeted drug carriers via biotin-streptavidin affinity.\n\u003cbr\u003eImmunoassays \u0026amp; Biochemical Assays: Improves detection sensitivity in ELISA, western blotting, and lateral flow assays.\u003c\/p\u003e","brand":"Polysciences","offers":[{"title":"26150-1 (1 g)","offer_id":46425797132502,"sku":"26150-1","price":1304.91,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0713\/5258\/2358\/files\/NEW_26150_2_5a05f1af-f585-411b-8c7f-f961ea413484.png?v=1738252677"},{"product_id":"biotin-peg-nhs-mp-5000","title":"Biotin PEG NHS, Mp 5000","description":"\u003cp\u003eBiotin PEG NHS is an activated biotinylated PEG linker that contains an N-hydroxysuccinimide (NHS) ester for rapid conjugation to primary amines on biomolecules such as proteins, antibodies, and peptides. The NHS ester enables efficient and stable amide bond formation under mild conditions, while the PEG spacer enhances solubility, reduces aggregation, and minimizes steric hindrance in biotin-avidin interactions.\n\u003cbr\u003eApplications:\n\u003cbr\u003eProtein \u0026amp; Antibody Labeling: Facilitates rapid biotinylation of biomolecules for affinity purification and assay development.\n\u003cbr\u003eNanoparticle \u0026amp; Surface Functionalization: Enhances stability and specificity in biosensor platforms.\n\u003cbr\u003eDrug Delivery \u0026amp; Targeting: Used in targeted drug carriers via biotin-streptavidin affinity.\n\u003cbr\u003eImmunoassays \u0026amp; Biochemical Assays: Improves detection sensitivity in ELISA, western blotting, and lateral flow assays.\u003c\/p\u003e","brand":"Polysciences","offers":[{"title":"26151-1 (1 g)","offer_id":46425797165270,"sku":"26151-1","price":1311.27,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0713\/5258\/2358\/files\/NEW_26151_755f974e-8ca9-424b-b519-7a2c8cbfaf33.png?v=1738252677"},{"product_id":"biotin-peg-nhs-mp-10000","title":"Biotin PEG NHS, Mp 10000","description":"\u003cp\u003eBiotin PEG NHS is an activated biotinylated PEG linker that contains an N-hydroxysuccinimide (NHS) ester for rapid conjugation to primary amines on biomolecules such as proteins, antibodies, and peptides. The NHS ester enables efficient and stable amide bond formation under mild conditions, while the PEG spacer enhances solubility, reduces aggregation, and minimizes steric hindrance in biotin-avidin interactions.\n\u003cbr\u003eApplications:\n\u003cbr\u003eProtein \u0026amp; Antibody Labeling: Facilitates rapid biotinylation of biomolecules for affinity purification and assay development.\n\u003cbr\u003eNanoparticle \u0026amp; Surface Functionalization: Enhances stability and specificity in biosensor platforms.\n\u003cbr\u003eDrug Delivery \u0026amp; Targeting: Used in targeted drug carriers via biotin-streptavidin affinity.\n\u003cbr\u003eImmunoassays \u0026amp; Biochemical Assays: Improves detection sensitivity in ELISA, western blotting, and lateral flow assays.\u003c\/p\u003e","brand":"Polysciences","offers":[{"title":"26152-1 (1 g)","offer_id":46425797198038,"sku":"26152-1","price":1398.27,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0713\/5258\/2358\/files\/NEW_26152_a31521e4-d3d7-41be-820c-a2e7811712cd.png?v=1738252677"},{"product_id":"boc-amine-peg-nhs-mp-3000","title":"Boc-amine PEG NHS, Mp 3000","description":"\u003cp\u003eBoc-Amine PEG NHS is a bifunctional PEG reagent with a Boc-protected amine at one end and an NHS ester at the other. The NHS group allows rapid conjugation to amine-containing biomolecules, while the Boc-protected end can be selectively deprotected under acidic conditions to expose a primary amine for further modification. This stepwise functionalization capability makes it valuable for precise bioconjugation, targeted drug delivery, and biomaterial engineering.\u003c\/p\u003e\n\n\u003cp\u003eApplications:\n\u003cbr\u003eStepwise Bioconjugation: Enables sequential chemical modifications in protein and peptide engineering.\n\u003cbr\u003eControlled Drug Delivery: Facilitates site-specific PEGylation of drug molecules.\n\u003cbr\u003eSurface \u0026amp; Nanoparticle Coating: Functionalizes biomaterial surfaces for biosensors and diagnostics.\n\u003cbr\u003eBiomedical Research \u0026amp; Assays: Enhances specificity and efficiency in bioassay development.\u003c\/p\u003e","brand":"Polysciences","offers":[{"title":"26162-100 (100 mg)","offer_id":46425798574294,"sku":"26162-100","price":293.55,"currency_code":"USD","in_stock":true},{"title":"26162-500 (500 mg)","offer_id":46425798607062,"sku":"26162-500","price":707.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0713\/5258\/2358\/files\/NEW_26162_e8de8543-a95c-4858-809e-ca157e9c9606.png?v=1738252678"},{"product_id":"boc-amine-peg-nhs-mp-5000","title":"Boc-amine PEG NHS, Mp 5000","description":"\u003cp\u003eBoc-Amine PEG NHS is a bifunctional PEG reagent with a Boc-protected amine at one end and an NHS ester at the other. The NHS group allows rapid conjugation to amine-containing biomolecules, while the Boc-protected end can be selectively deprotected under acidic conditions to expose a primary amine for further modification. This stepwise functionalization capability makes it valuable for precise bioconjugation, targeted drug delivery, and biomaterial engineering.\u003c\/p\u003e\n\n\u003cp\u003eApplications:\n\u003cbr\u003eStepwise Bioconjugation: Enables sequential chemical modifications in protein and peptide engineering.\n\u003cbr\u003eControlled Drug Delivery: Facilitates site-specific PEGylation of drug molecules.\n\u003cbr\u003eSurface \u0026amp; Nanoparticle Coating: Functionalizes biomaterial surfaces for biosensors and diagnostics.\n\u003cbr\u003eBiomedical Research \u0026amp; Assays: Enhances specificity and efficiency in bioassay development.\u003c\/p\u003e","brand":"Polysciences","offers":[{"title":"26163-100 (100 mg)","offer_id":46425798934742,"sku":"26163-100","price":293.55,"currency_code":"USD","in_stock":true},{"title":"26163-500 (500 mg)","offer_id":46425798967510,"sku":"26163-500","price":765.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0713\/5258\/2358\/files\/NEW_26162_1_f12c2e36-e720-423c-9d55-cf6ece131481.png?v=1738252677"},{"product_id":"boc-amine-peg-nhs-mp-10000","title":"Boc-amine PEG NHS, Mp 10000","description":"\u003cp\u003eBoc-Amine PEG NHS is a bifunctional PEG reagent with a Boc-protected amine at one end and an NHS ester at the other. 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