DMTAP (1,2-dimyristoyl-3-trimethylammonium-propane chloride)
C34H68NO4Cl
DMTAP chloride (1,2-dimyristoyl-3-trimethylammonium-propane chloride) is a saturated cationic lipid with applications in transfection and drug delivery. When combined with nucleic acids, this lipid forms a liposome that efficiently condenses and transports the genetic material into the cell.
Synonyms: (1,2-dimyristoyl-3-trimethylammonium-propane chloride)
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Ghosh, M., Ren, G., Simonsen, J., & Ryan, R. (2014). Cationic lipid nanodisks as an siRNA delivery vehicle. Biochemistry and Cell Biology 92(3).
Lou, G., Anderluzzi, G., Schmidt, S., Woods, S., Gallorini, S., Brazzoli, M., Guisti, F., Ferlenghi, I., Johnson, R., Roberts, C., O'Hagan, D., Baudner, B., & Perrie, Y. (2020). Delivery of self-amplifying mRNA vaccines by cationic lipid nanoparticles: The impact of cationic lipid selection. Journal of Controlled Release. 325: 370-379.