{"product_id":"poly-dl-lactide-co-glycolide-50-50-iv-0-2-acid-terminated","title":"Poly(D,L-lactide-co-glycolide), 50:50, IV 0.2 dL\/g, acid-terminated","description":"\u003cdiv class=\"pdp-content-block\"\u003e\n  \u003cdiv class=\"pdp-eyebrow\"\u003e⟡ Biodegradable Polymers \/ PLGA\u003c\/div\u003e\n\n  \u003ch2\u003ePoly(D,L-lactide-co-glycolide), 50:50, IV 0.2 dL\/g, acid-terminated\u003c\/h2\u003e\n\n  \u003cp\u003e\u003cstrong\u003ePoly(D,L-lactide-co-glycolide) (PLGA), 50:50, IV 0.2 dL\/g, acid-terminated\u003c\/strong\u003e is a biodegradable copolymer composed of D,L-lactide and glycolide in an equimolar ratio. This 50:50 composition is associated with relatively rapid hydrolytic degradation, while the low inherent viscosity (IV 0.2 dL\/g) indicates a lower molecular weight polymer suitable for applications requiring shorter residence times and faster material breakdown.\u003c\/p\u003e\n\n  \u003cp\u003eThe acid-terminated end groups provide reactive functionality that can be used for further chemical modification, conjugation, or controlled interaction with active compounds. This makes the material particularly useful in research settings where degradation rate, release profile, and polymer–drug interactions must be tuned.\u003c\/p\u003e\n\n  \u003chr\u003e\n\n  \u003ch3\u003eKey Features \u0026amp; Benefits\u003c\/h3\u003e\n  \u003cul\u003e\n    \u003cli\u003e\n\u003cstrong\u003e50:50 lactide:glycolide ratio:\u003c\/strong\u003e supports relatively fast and predictable hydrolytic degradation\u003c\/li\u003e\n    \u003cli\u003e\n\u003cstrong\u003eLow inherent viscosity (0.2 dL\/g):\u003c\/strong\u003e indicates lower molecular weight for shorter degradation timelines\u003c\/li\u003e\n    \u003cli\u003e\n\u003cstrong\u003eAcid-terminated polymer chains:\u003c\/strong\u003e enables chemical modification and conjugation strategies\u003c\/li\u003e\n    \u003cli\u003e\n\u003cstrong\u003eBiodegradable and biocompatible:\u003c\/strong\u003e widely used in biomedical and pharmaceutical research\u003c\/li\u003e\n    \u003cli\u003e\n\u003cstrong\u003eWell-characterized material system:\u003c\/strong\u003e supported by extensive literature and regulatory familiarity\u003c\/li\u003e\n  \u003c\/ul\u003e\n\n  \u003chr\u003e\n\n  \u003ch3\u003eProduct Details\u003c\/h3\u003e\n  \u003cul\u003e\n    \u003cli\u003e\n\u003cstrong\u003eProduct name:\u003c\/strong\u003e Poly(D,L-lactide-co-glycolide), 50:50, IV 0.2 dL\/g, acid-terminated\u003c\/li\u003e\n    \u003cli\u003e\n\u003cstrong\u003eProduct number:\u003c\/strong\u003e 26269\u003c\/li\u003e\n    \u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 26780-50-7\u003c\/li\u003e\n    \u003cli\u003e\n\u003cstrong\u003eCopolymer composition:\u003c\/strong\u003e 50:50 D,L-lactide:glycolide\u003c\/li\u003e\n    \u003cli\u003e\n\u003cstrong\u003eInherent viscosity (IV):\u003c\/strong\u003e 0.2 dL\/g\u003c\/li\u003e\n    \u003cli\u003e\n\u003cstrong\u003eEnd group:\u003c\/strong\u003e Acid-terminated\u003c\/li\u003e\n    \u003cli\u003e\n\u003cstrong\u003ePolymer type:\u003c\/strong\u003e Biodegradable aliphatic polyester\u003c\/li\u003e\n  \u003c\/ul\u003e\n\n  \u003chr\u003e\n\n  \u003ch3\u003eTypical Applications\u003c\/h3\u003e\n\n  \u003cp\u003e\u003cstrong\u003eDrug delivery research\u003c\/strong\u003e\u003cbr\u003e\n  Used in the development of microspheres, nanoparticles, and matrix systems where controlled degradation and release are required over shorter timeframes.\u003c\/p\u003e\n\n  \u003cp\u003e\u003cstrong\u003eBiodegradable material design\u003c\/strong\u003e\u003cbr\u003e\n  Suitable for applications requiring temporary structural support or resorbable materials with faster breakdown profiles.\u003c\/p\u003e\n\n  \u003cp\u003e\u003cstrong\u003ePolymer conjugation and modification\u003c\/strong\u003e\u003cbr\u003e\n  Acid end groups enable coupling reactions for attaching drugs, ligands, or functional molecules.\u003c\/p\u003e\n\n  \u003cp\u003e\u003cstrong\u003eBiomedical and pharmaceutical studies\u003c\/strong\u003e\u003cbr\u003e\n  Frequently used in research involving resorbable systems, tissue engineering scaffolds, and delivery platforms.\u003c\/p\u003e\n\n  \u003chr\u003e\n\n  \u003ch3\u003eFunctional Role\u003c\/h3\u003e\n  \u003cp\u003eThis PLGA grade functions as a \u003cstrong\u003ebiodegradable polymer matrix\u003c\/strong\u003e that undergoes hydrolytic degradation into lactic and glycolic acid derivatives. The relatively low molecular weight and 50:50 composition contribute to faster water uptake and chain cleavage, while the acid end groups provide opportunities for further chemical interaction or formulation tuning.\u003c\/p\u003e\n\n  \u003chr\u003e\n\n  \u003ch3\u003eWhy Molecular Weight and Composition Matter\u003c\/h3\u003e\n  \u003cp\u003eThe degradation rate of PLGA is influenced by both copolymer ratio and molecular weight. A 50:50 ratio typically results in faster degradation compared to lactide-rich variants, while lower inherent viscosity corresponds to shorter polymer chains and reduced structural persistence. Together, these factors make this grade appropriate for applications requiring degradation on shorter timescales.\u003c\/p\u003e\n\n  \u003cp\u003eFor more guidance, see our \u003ca href=\"\/blogs\/news\/how-to-choose-polymer-molecular-weight\"\u003epolymer molecular weight selection guide\u003c\/a\u003e.\u003c\/p\u003e\n\n  \u003chr\u003e\n\n  \u003ch3\u003eHandling \u0026amp; Storage\u003c\/h3\u003e\n  \u003cul\u003e\n    \u003cli\u003eStore in a cool, dry environment in a tightly sealed container.\u003c\/li\u003e\n    \u003cli\u003eProtect from moisture to minimize premature hydrolysis.\u003c\/li\u003e\n    \u003cli\u003eHandle using appropriate laboratory safety practices.\u003c\/li\u003e\n    \u003cli\u003eConsult the SDS for detailed handling and storage recommendations.\u003c\/li\u003e\n  \u003c\/ul\u003e\n\n  \u003chr\u003e\n\n  \u003ch2\u003eFAQ\u003c\/h2\u003e\n  \u003cp\u003eClick a question to expand.\u003c\/p\u003e\n\n  \u003cdetails\u003e\n    \u003csummary\u003e\u003cstrong\u003eWhat does 50:50 PLGA mean?\u003c\/strong\u003e\u003c\/summary\u003e\n    \u003cp\u003eIt refers to a 1:1 molar ratio of lactide and glycolide, which is commonly associated with faster degradation compared to other PLGA compositions.\u003c\/p\u003e\n  \u003c\/details\u003e\n\n  \u003cdetails\u003e\n    \u003csummary\u003e\u003cstrong\u003eWhat does IV 0.2 dL\/g indicate?\u003c\/strong\u003e\u003c\/summary\u003e\n    \u003cp\u003eIt reflects a relatively low molecular weight polymer, which typically correlates with faster degradation and lower mechanical strength.\u003c\/p\u003e\n  \u003c\/details\u003e\n\n  \u003cdetails\u003e\n    \u003csummary\u003e\u003cstrong\u003eWhat is acid-terminated PLGA used for?\u003c\/strong\u003e\u003c\/summary\u003e\n    \u003cp\u003eAcid-terminated PLGA can be used for conjugation, formulation tuning, or interactions with active compounds in drug delivery systems.\u003c\/p\u003e\n  \u003c\/details\u003e\n\n  \u003cdetails\u003e\n    \u003csummary\u003e\u003cstrong\u003eHow fast does this PLGA degrade?\u003c\/strong\u003e\u003c\/summary\u003e\n    \u003cp\u003eDegradation rate depends on conditions, but 50:50, low molecular weight PLGA is generally used for shorter-term applications compared to higher molecular weight or lactide-rich variants.\u003c\/p\u003e\n  \u003c\/details\u003e\n\n  \u003cdetails\u003e\n    \u003csummary\u003e\u003cstrong\u003eIs PLGA biocompatible?\u003c\/strong\u003e\u003c\/summary\u003e\n    \u003cp\u003ePLGA is widely studied and used in biomedical research due to its biodegradability and compatibility with biological systems.\u003c\/p\u003e\n  \u003c\/details\u003e\n\u003c\/div\u003e","brand":"Polysciences","offers":[{"title":"26269-1 (1 g)","offer_id":46425815318742,"sku":"26269-1","price":75.0,"currency_code":"USD","in_stock":true},{"title":"26269-10 (10 g)","offer_id":46425815351510,"sku":"26269-10","price":358.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0713\/5258\/2358\/files\/NEW_pdlg_acid_2_1_7e864dee-a7bb-41ad-a247-e7cedca7f814.png?v=1738252552","url":"https:\/\/polysciences.com\/products\/poly-dl-lactide-co-glycolide-50-50-iv-0-2-acid-terminated","provider":"Polysciences","version":"1.0","type":"link"}