{"product_id":"products-poly-d-l-lactide-co-glycolide-85-15-iv-0-85-dl-g","title":"Poly(D,L-lactide-co-glycolide), 85:15, IV 0.85 dL\/g","description":"\u003cp\u003ePoly(D,L-lactide-co-glycolide) (PLGA) 85:15 is a hydrolytically degradable aliphatic polyester copolymer of D,L-lactide and glycolide. This grade has an 85:15 D,L-lactide:glycolide composition and a nominal inherent viscosity of 0.85 dL\/g, with a specification range of 0.76–0.85 dL\/g.\u003c\/p\u003e\n\n\u003cp\u003eHydrolysis of the polyester backbone produces progressive chain scission and loss of molar mass. Lactide:glycolide composition is one determinant of degradation behavior; molar mass and molar-mass distribution, end-group chemistry, specimen geometry, processing history, water uptake, and environmental conditions can also affect hydrolysis and mass loss.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eSynonyms:\u003c\/strong\u003e PLGA; D,L-lactide \u0026amp; glycolide copolymer; poly(D,L-lactide-co-glycolide).\u003c\/p\u003e\n\n\u003ch2\u003eKey Properties\u003c\/h2\u003e\n\n\u003cul\u003e\n\u003cli\u003eProduct number: 23989\u003c\/li\u003e\n\u003cli\u003ePolymer: Poly(D,L-lactide-co-glycolide) (PLGA)\u003c\/li\u003e\n\u003cli\u003eCopolymer composition: 85:15 D,L-lactide:glycolide\u003c\/li\u003e\n\u003cli\u003eCAS number: 26780-50-7\u003c\/li\u003e\n\u003cli\u003eNominal inherent viscosity: 0.85 dL\/g\u003c\/li\u003e\n\u003cli\u003eInherent viscosity specification: 0.76–0.85 dL\/g\u003c\/li\u003e\n\u003cli\u003eGlass transition temperature (Tg): 50–55°C\u003c\/li\u003e\n\u003cli\u003eAppearance: White to tan pelletized solid\u003c\/li\u003e\n\u003cli\u003eResidual monomer specification: ≤2.0 mole %\u003c\/li\u003e\n\u003cli\u003eResidual tin specification: ≤200 ppm\u003c\/li\u003e\n\u003cli\u003eBacterial endotoxin specification: ≤0.5 EU\/mL\u003c\/li\u003e\n\u003cli\u003eIdentity: FT-IR conforms to reference\u003c\/li\u003e\n\u003cli\u003eStorage: -20°C\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003eApplications\u003c\/h2\u003e\n\n\u003ch3\u003eHydrolytic Degradation Studies\u003c\/h3\u003e\n\u003cp\u003ePLGA 85:15 compositions are used to investigate changes in polymer molar mass, mass loss, morphology, and material properties during hydrolysis. Experimental degradation behavior depends on polymer characteristics together with specimen geometry, porosity, processing history, temperature, pH, and the surrounding medium.\u003c\/p\u003e\n\n\u003ch3\u003eMicrosphere \u0026amp; Nanoparticle Formulation Research\u003c\/h3\u003e\n\u003cp\u003ePLGA 85:15 has been studied in microsphere and nanoparticle formulations prepared by emulsion, solvent-evaporation, microfluidic, and related processing methods. Particle size, morphology, encapsulation behavior, and release profiles depend on the complete formulation and processing conditions rather than copolymer ratio alone.\u003c\/p\u003e\n\n\u003ch3\u003eControlled-Release Research\u003c\/h3\u003e\n\u003cp\u003ePLGA 85:15 has been investigated as a degradable matrix in controlled-release systems. Release can involve diffusion, polymer hydration, chain scission, pore formation, and erosion, with relative contributions determined by polymer characteristics, incorporated material, device or particle geometry, and processing conditions.\u003c\/p\u003e\n\n\u003ch3\u003ePorous Polymer Structures\u003c\/h3\u003e\n\u003cp\u003ePLGA 85:15 has also been studied in porous structures where pore size, porosity, specimen dimensions, and fabrication method influence water penetration and degradation behavior.\u003c\/p\u003e\n\n\u003ch2\u003eSolubility \u0026amp; Grade Selection\u003c\/h2\u003e\n\n\u003cul\u003e\n\u003cli\u003eSoluble in chloroform\u003c\/li\u003e\n\u003cli\u003eSoluble in acetone\u003c\/li\u003e\n\u003cli\u003eSoluble in ethyl acetate\u003c\/li\u003e\n\u003cli\u003eSoluble in tetrahydrofuran (THF)\u003c\/li\u003e\n\u003cli\u003eThe 85:15 designation identifies the D,L-lactide:glycolide composition\u003c\/li\u003e\n\u003cli\u003eThe 0.85 dL\/g designation refers to the nominal inherent-viscosity grade\u003c\/li\u003e\n\u003cli\u003eInherent viscosity is not a direct molecular-weight specification\u003c\/li\u003e\n\u003cli\u003ePLGA grades sharing CAS 26780-50-7 may differ in copolymer composition, viscosity grade, molar mass, end-group chemistry, architecture, and other polymer characteristics\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eUnder otherwise comparable conditions, lactide-rich PLGA compositions such as 85:15 generally hydrolyze more slowly than 50:50 PLGA. Direct experimental comparisons should control additional polymer variables, including inherent viscosity or molar mass and end-group chemistry, rather than attributing differences solely to lactide:glycolide ratio.\u003c\/p\u003e\n\n\u003cp\u003eAdditional compositions and viscosity grades include \u003ca href=\"https:\/\/polysciences.com\/products\/poly-d-l-lactide-co-glycolide-75-25-iv-0-65-dl-g\"\u003ePLGA 75:25, IV 0.65 dL\/g\u003c\/a\u003e, \u003ca href=\"https:\/\/polysciences.com\/products\/poly-d-l-lactide-co-glycolide-50-50-iv-0-6-dl-g\"\u003ePLGA 50:50, IV 0.6 dL\/g\u003c\/a\u003e, and \u003ca href=\"https:\/\/polysciences.com\/products\/poly-d-l-lactide-co-glycolide-50-50-iv-1-0-dl-g\"\u003ePLGA 50:50, IV 1.0 dL\/g\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch2\u003eApplication Tips\u003c\/h2\u003e\n\n\u003cul\u003e\n\u003cli\u003eProtect the polymer from moisture during storage, weighing, and processing\u003c\/li\u003e\n\u003cli\u003eKeep polymer grade, lot, formulation composition, and processing conditions constant when comparing degradation experiments\u003c\/li\u003e\n\u003cli\u003eFor solvent-based processing, select the solvent with consideration for polymer concentration, formulation components, precipitation conditions, and solvent-removal method\u003c\/li\u003e\n\u003cli\u003eWhen comparing PLGA compositions, avoid changing inherent viscosity or other polymer characteristics unintentionally between experimental groups\u003c\/li\u003e\n\u003cli\u003eUse direct molar-mass characterization when interpretation depends on molecular weight or molecular-weight distribution rather than inferring these quantities from inherent viscosity alone\u003c\/li\u003e\n\u003cli\u003eRecord specimen or particle geometry, porosity, and processing history when interpreting hydrolysis, mass-loss, or release data\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003eHandling \u0026amp; Storage\u003c\/h2\u003e\n\n\u003cul\u003e\n\u003cli\u003eStore at -20°C\u003c\/li\u003e\n\u003cli\u003eKeep away from moisture\u003c\/li\u003e\n\u003cli\u003eKeep the container closed when not in use\u003c\/li\u003e\n\u003cli\u003eHandle in a well-ventilated laboratory workspace\u003c\/li\u003e\n\u003cli\u003eWear protective gloves, safety glasses, and suitable protective clothing\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003chr class=\"pdp-divider\"\u003e\n\n\u003ch3\u003eWhy Choose Polysciences?\u003c\/h3\u003e\n\n\u003cdiv class=\"pdp-trust-signals\" style=\"display:grid;grid-template-columns:repeat(2,1fr);gap:14px;max-width:560px;margin:24px 0;\"\u003e\n  \n  \u003cdiv style=\"border:1px solid #17458f;border-radius:10px;padding:18px 14px;text-align:center;background:#fff;\"\u003e\n    \u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0713\/5258\/2358\/files\/Research_Labs.png?v=1778099422\" alt=\"Research laboratories icon\" style=\"width:42px;height:42px;object-fit:contain;display:block;margin:0 auto 12px;\"\u003e\n    \u003cdiv style=\"font-family:inherit;font-size:14px;line-height:1.3;font-weight:700;color:#12386b;\"\u003e\n      Trusted by 6,000+ Researchers Worldwide\n    \u003c\/div\u003e\n  \u003c\/div\u003e\n\n  \u003cdiv style=\"border:1px solid #17458f;border-radius:10px;padding:18px 14px;text-align:center;background:#fff;\"\u003e\n    \u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0713\/5258\/2358\/files\/Peer-Reviewed.png?v=1778099423\" alt=\"Peer reviewed studies icon\" style=\"width:42px;height:42px;object-fit:contain;display:block;margin:0 auto 12px;\"\u003e\n    \u003cdiv style=\"font-family:inherit;font-size:14px;line-height:1.3;font-weight:700;color:#12386b;\"\u003e\n      Cited in Thousands of Peer-Reviewed Studies\n    \u003c\/div\u003e\n  \u003c\/div\u003e\n\n  \u003cdiv style=\"border:1px solid #17458f;border-radius:10px;padding:18px 14px;text-align:center;background:#fff;\"\u003e\n    \u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0713\/5258\/2358\/files\/USA.png?v=1778099422\" alt=\"Made in USA icon\" style=\"width:42px;height:42px;object-fit:contain;display:block;margin:0 auto 12px;\"\u003e\n    \u003cdiv style=\"font-family:inherit;font-size:14px;line-height:1.3;font-weight:700;color:#12386b;\"\u003e\n      U.S. Manufacturing \u0026amp; Global Distribution\n    \u003c\/div\u003e\n  \u003c\/div\u003e\n\n  \u003cdiv style=\"border:1px solid #17458f;border-radius:10px;padding:18px 14px;text-align:center;background:#fff;\"\u003e\n    \u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0713\/5258\/2358\/files\/Delivery.png?v=1778099422\" alt=\"Global delivery icon\" style=\"width:42px;height:42px;object-fit:contain;display:block;margin:0 auto 12px;\"\u003e\n    \u003cdiv style=\"font-family:inherit;font-size:14px;line-height:1.3;font-weight:700;color:#12386b;\"\u003e\n      Reliable Delivery to 40+ Countries\n    \u003c\/div\u003e\n  \u003c\/div\u003e\n\n\u003c\/div\u003e\n\n\u003ch2\u003eFAQ\u003c\/h2\u003e\n\u003cp\u003eClick a question to expand.\u003c\/p\u003e\n\n\u003cdiv class=\"faq-accordion\"\u003e\n\n\u003cdetails\u003e\n\u003csummary\u003e1. What is PLGA 85:15?\u003c\/summary\u003e\n\u003cp\u003ePLGA 85:15 is poly(D,L-lactide-co-glycolide) containing D,L-lactide and glycolide in an 85:15 composition. It is a hydrolytically degradable polyester used in polymer-degradation, particle-formulation, controlled-release, and related materials research.\u003c\/p\u003e\n\u003c\/details\u003e\n\n\u003cdetails\u003e\n\u003csummary\u003e2. What does the 85:15 ratio in PLGA mean?\u003c\/summary\u003e\n\u003cp\u003eThe 85:15 designation refers to the D,L-lactide:glycolide composition of the copolymer. Copolymer composition affects water uptake and hydrolytic degradation, but it is not the only variable controlling PLGA behavior.\u003c\/p\u003e\n\u003c\/details\u003e\n\n\u003cdetails\u003e\n\u003csummary\u003e3. What does IV 0.85 dL\/g mean for this PLGA grade?\u003c\/summary\u003e\n\u003cp\u003eThis grade has a nominal inherent viscosity of 0.85 dL\/g and a specification range of 0.76–0.85 dL\/g. Inherent viscosity is a solution-viscosity measurement related to polymer chain dimensions under defined measurement conditions; it should not be interpreted as a direct molecular-weight value.\u003c\/p\u003e\n\u003c\/details\u003e\n\n\u003cdetails\u003e\n\u003csummary\u003e4. Is inherent viscosity the same as molecular weight?\u003c\/summary\u003e\n\u003cp\u003eNo. Inherent viscosity and molecular weight are related polymer characteristics, but they are not interchangeable. Conversion of viscosity data to molecular weight requires an appropriate polymer-solvent-temperature relationship and calibration.\u003c\/p\u003e\n\u003c\/details\u003e\n\n\u003cdetails\u003e\n\u003csummary\u003e5. What is the CAS number for PLGA 85:15?\u003c\/summary\u003e\n\u003cp\u003eThe CAS number is 26780-50-7. The same CAS number can apply to PLGA materials with different lactide:glycolide compositions and polymer characteristics, so ratio and viscosity grade should also be considered when selecting a polymer.\u003c\/p\u003e\n\u003c\/details\u003e\n\n\u003cdetails\u003e\n\u003csummary\u003e6. What solvents dissolve this PLGA 85:15 grade?\u003c\/summary\u003e\n\u003cp\u003eSolvents listed for this grade are chloroform, acetone, ethyl acetate, and tetrahydrofuran (THF).\u003c\/p\u003e\n\u003c\/details\u003e\n\n\u003cdetails\u003e\n\u003csummary\u003e7. What is the glass transition temperature of this PLGA?\u003c\/summary\u003e\n\u003cp\u003eThe glass transition temperature (Tg) is 50–55°C.\u003c\/p\u003e\n\u003c\/details\u003e\n\n\u003cdetails\u003e\n\u003csummary\u003e8. How does PLGA 85:15 differ from PLGA 50:50?\u003c\/summary\u003e\n\u003cp\u003ePLGA 85:15 contains more lactide and less glycolide than PLGA 50:50. Under otherwise comparable conditions, the more lactide-rich composition generally shows slower hydrolytic degradation. Meaningful comparisons should also account for inherent viscosity or molar mass, molecular-weight distribution, end-group chemistry, geometry, and processing conditions.\u003c\/p\u003e\n\u003c\/details\u003e\n\n\u003cdetails\u003e\n\u003csummary\u003e9. Is PLGA 85:15 the same as poly(D,L-lactide)?\u003c\/summary\u003e\n\u003cp\u003eNo. Poly(D,L-lactide) is a lactide homopolymer. PLGA 85:15 is a copolymer containing both D,L-lactide and glycolide repeat units.\u003c\/p\u003e\n\u003c\/details\u003e\n\n\u003cdetails\u003e\n\u003csummary\u003e10. What quality specifications are defined for this PLGA grade?\u003c\/summary\u003e\n\u003cp\u003eThe specification includes inherent viscosity of 0.76–0.85 dL\/g, residual monomer ≤2.0 mole %, residual tin ≤200 ppm, bacterial endotoxin ≤0.5 EU\/mL, and FT-IR identity conforming to reference.\u003c\/p\u003e\n\u003c\/details\u003e\n\n\u003cdetails\u003e\n\u003csummary\u003e11. How should PLGA 85:15 be stored?\u003c\/summary\u003e\n\u003cp\u003eStore at -20°C and protect the polymer from moisture.\u003c\/p\u003e\n\u003c\/details\u003e\n\n\u003cdetails\u003e\n\u003csummary\u003e12. Can larger quantities of PLGA 85:15 be requested?\u003c\/summary\u003e\n\u003cp\u003eFor quantities beyond the standard offering, use the \u003ca href=\"https:\/\/polysciences.com\/pages\/contact-us?inquiry_type=Bulk+Inquiry\"\u003ebulk-quote option\u003c\/a\u003e.\u003c\/p\u003e\n\u003c\/details\u003e\n\n\u003c\/div\u003e\n\n\u003ch2\u003eSafety \u0026amp; Documentation\u003c\/h2\u003e\n\n\u003cp\u003eReview the \u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0713\/5258\/2358\/files\/Spec-23989.pdf\"\u003eProduct Specification\u003c\/a\u003e for product-specific quality criteria and the \u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0713\/5258\/2358\/files\/2026_SDS_23989.pdf\"\u003eSafety Data Sheet\u003c\/a\u003e for handling, storage, and safety information.\u003c\/p\u003e","brand":"Polysciences","offers":[{"title":"23989-1 (1 g)","offer_id":46425730646230,"sku":"23989-1","price":84.0,"currency_code":"USD","in_stock":true},{"title":"23989-5 (5 g)","offer_id":46425730678998,"sku":"23989-5","price":370.59,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0713\/5258\/2358\/files\/23989_3c1a654b-8a46-4e5b-b3fd-c6a5bd6d30f2.jpg?v=1736778657","url":"https:\/\/polysciences.com\/products\/products-poly-d-l-lactide-co-glycolide-85-15-iv-0-85-dl-g","provider":"Polysciences","version":"1.0","type":"link"}