Methoxy PEG carboxylic acid, Mp 2000

Methoxy PEG carboxylic acid (mPEG-COOH) is a carboxyl-functionalized PEG derivative, providing a reactive site for amide or ester bond formation. The methoxy end ensures hydrophilicity, while the carboxyl (-COOH) group enables conjugation to amines and hydroxyl-containing molecules via EDC/NHS or carbodiimide coupling. It is widely used in bioconjugation, polymer modifications, and surface coatings.

Applications:
Bioconjugation & PEGylation: Used to covalently modify proteins, peptides, and nanoparticles, enhancing stability and bioavailability.
Hydrogel & Polymer Synthesis: Incorporated into crosslinked PEG networks, improving mechanical properties and biocompatibility.
Surface Functionalization: Functionalized onto biosensors, implants, and drug delivery carriers to enhance hydrophilicity and reduce biofouling.
Drug Delivery Systems: Applied in controlled release formulations, where PEGylation improves solubility and prolongs circulation time.