Polyethylene Glycol (PEG) Hydrogels

Empowering Innovation in Every Drop

Biocompatible Solutions for Advanced Applications

PEG hydrogels are hydrophilic, three-dimensional polymeric networks known for their ability to retain water while maintaining structural integrity. As a versatile, biocompatible polymer, PEG serves as the backbone of numerous hydrogel formulations, offering flexibility and chemical modification potential.

Browse PEGs & Derivatives
PEG hydrogel in petri dish with blue liquid and bubbles
Close-up of PEG hydrogel texture with swirling fluid patterns

Key Advantages of PEG Hydrogels:

  • Absorb and retain significant amounts of water.
  • Biocompatible and low-toxicity polymer.
  • Tunable mechanical strength, swelling, and degradation rates.
  • Suitable for applications such as tissue engineering, drug delivery, wound healing, and 3D bioprinting.
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PEGylation and Its Applications

PEGylation involves attaching PEG chains to therapeutic molecules to enhance their stability and performance.

Benefits of PEGylation:

  • Reduces immunogenicity and proteolytic degradation.
  • Improves pharmacokinetics and molecule stability.
  • Achieved with derivatives like PEG-NHS (targeting amines) or PEG-maleimides (targeting thiols).

PEGylation enhances the interaction of therapeutic agents with biological systems, boosting their efficacy and improving usability.

Macro shot of PEG crystals and water droplets on surface

Physical and Chemical Properties of PEG

PEG’s unique physical and chemical properties make it a versatile material for various applications:

  • Physical Form: Varies with molecular weight:
  • 200–800 MW: Clear, viscous liquids.
  • 1000–3000 MW: Paste to waxy solids.
  • 3000+ MW: Free-flowing powders.
  • Solubility: Highly soluble in water and versatile solvents like DMSO, chloroform, methanol, and more.
  • Thermal Stability: Maintains stability across a broad temperature range, ideal for diverse applications.

These physical and chemical properties enable PEG to adapt to a wide range of applications, from biomedical solutions to industrial innovations. Its versatility and reliability make it a foundational material for research and development.

Explore PEGs & Derivatives

Functional and Biocompatible Features of PEG

PEG is engineered for optimal functionality and compatibility with sensitive formulations:

  • Functionality:
  • Homobifunctional (X-PEG-X) or heterobifunctional (X-PEG-Y) for tailored reactivity.
  • Monofunctional (mPEG-X) to inhibit unwanted crosslinking reactions.
  • Biocompatibility: Biologically safe, with end-group functionalities that minimize immune response.
  • Molecular Weight Variability: Available in a wide range of monodispersed molecular weights (PDI ≤ 1.2), ensuring customizable properties.
  • Non-Reactive Nature: Its chemically inert backbone makes it an excellent stabilizing agent for sensitive formulations.

The functionality and biocompatibility of PEG ensure its effectiveness in sensitive applications, supporting breakthroughs in drug delivery, medical devices, and advanced formulations. With tailored solutions, PEG continues to drive innovation.

Circular PEG hydrogel with visible polymer network

PEG Derivatives for Hydrogel Crosslinking

PEG derivatives offer a wide range of functionalities tailored to hydrogel synthesis. Below are some commonly used PEG derivatives and their key features.

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  • A versatile crosslinker for photo-initiated polymerization.
  • Used in tissue engineering and drug delivery systems due to tunable stiffness and degradation rates.
PEG Diacrylate chemical structure for crosslinking

Click here to search our PEGDA products

Poly(ethylene glycol) diacrylate, MW 20000 (PEGDA 20K)

Product Number
    26280
    €195
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    NT$ 9342
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    ₹ 25680.11
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$194.62

Polyethylene glycol diacrylate (PEGDA 400)

Product Number
    01871
CAS #
    26570-48-9
    €281
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    NT$ 13445
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    ₹ 36959.20
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$280.10

Polyethylene glycol diacrylate (PEGDA 4000)

Product Number
    15246
CAS #
    26570-48-9
    €100
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    NT$ 4790
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    ₹ 13167.29
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$99.79

Poly(ethylene glycol) diacrylate, MW 35,000

Product Number
    26423
CAS #
    26570-48-9
    €144
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    NT$ 6912
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    ₹ 19000.80
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$144.00

Poly(ethylene glycol) diacrylate, MW 10000 (PEGDA 10K)

Product Number
    26279
    €204
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    NT$ 9768
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    ₹ 26851.83
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$203.50

Diethylene glycol diacrylate (DEGDA)

Product Number
    02215
CAS #
    4074-88-8
    €206
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    NT$ 9409
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    ₹ 37459.42
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$196.02

Poly(ethylene glycol) 1,000 diacrylate

Product Number
    25485
    €94
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    NT$ 4492
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    ₹ 12347.88
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$93.58

Triethylene glycol diacrylate (TriEGDA)

Product Number
    02655
CAS #
    1680-21-3
    €46
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    NT$ 1872
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    ₹ 5146.05
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$39.00
  • Similar to PEGDA but with enhanced rigidity due to methacrylate sterics.
  • Ideal for applications requiring higher mechanical strength.
PEG Dimethacrylate chemical structure with rigid linkage

Click here to search our PEGDMA products

Polyethylene glycol dimethacrylate (PEGDMA 1000)

Product Number
    15178
CAS #
    25852-47-5
    €654
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    NT$ 31392
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    ₹ 86295.30
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$654.00

Poly(ethylene glycol) dimethacrylate, MW 35,000

Product Number
    26424
CAS #
    25852-47-5
    €103
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    NT$ 4944
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    ₹ 13590.85
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$103.00

Poly(ethylene glycol) (20,000) dimethacrylate

Product Number
    25406
CAS #
    25852-47-5
    €851
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    NT$ 40803
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    ₹ 112165.42
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$850.06

Poly(ethylene glycol) (8000) dimethacrylate

Product Number
    25428
    €428
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    NT$ 20505
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    ₹ 56367.72
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$427.19

Tetraethylene glycol dimethacrylate, ≥ 85%

Product Number
    02654
CAS #
    109-17-1
    €152
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    NT$ 7268
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    ₹ 19978.55
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$151.41

Triethylene glycol dimethacrylate, min 95%

Product Number
    24034
CAS #
    109-16-0
    €80
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    NT$ 3788
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    ₹ 10414.81
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$78.93

Poly(ethylene glycol) 2000 dimethacrylate

Product Number
    26415
    €200
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    NT$ 9557
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    ₹ 26272.56
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$199.11

Ethylene Glycol Dimethacrylate (EGDMA), ≥ 99.7%

Product Number
    24896
CAS #
    97-90-5
    €51
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    NT$ 2393
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    ₹ 6577.71
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$49.85
  • Features terminal epoxides for robust covalent networks.
  • Suitable for applications demanding chemically stable hydrogels.
PEG Diglycidyl Ether chemical structure with terminal epoxides

Click here to search our PEGDGE products

Poly(ethylene glycol) diglycidyl ether (PEGDGE 400)

Product Number
    08210
CAS #
    72207-80-8
    €299
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    NT$ 14309
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    ₹ 39335.61
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$298.11

Poly(ethylene glycol) diglycidyl ether (PEGDGE 200)

Product Number
    08209
CAS #
    72207-80-8
    €315
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    NT$ 14899
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    ₹ 40955.96
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$310.39

Ethylene glycol diglycidyl ether (EGDGE)

Product Number
    01479
CAS #
    2224-15-9
    €51
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    NT$ 2393
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    ₹ 6579.03
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$49.86

Poly(ethylene glycol) diglycidyl ether (PEGDGE 1000)

Product Number
    24047
CAS #
    72207-80-8
    €215
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    NT$ 10227
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    ₹ 28113.27
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$213.06

Poly(ethylene glycol) diglycidyl ether (PEGDGE 600)

Product Number
    08211
CAS #
    72207-80-8
    Contact Us
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    Contact Us
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    Contact Us
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$0.00
  • Enables thiol-ene "click" chemistry for rapid hydrogel formation under mild conditions.
  • Particularly useful for encapsulating sensitive biological materials.
PEG Thiol structure for thiol-ene click chemistry

Click here to search our PEG Thiols

Biotin PEG thiol, Mp 5000

Product Number
    26154
    €1022
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    NT$ 49056
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    ₹ 117325.6
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$1,022.00

Tritythiol PEG NHS, Mp 10000

Product Number
    26227
    €2021
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$2,030.56

Tritythiol PEG NHS, Mp 5000

Product Number
    26226
    €2021
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    NT$ 97467
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$2,030.56

Tritythiol PEG NHS, Mp 3000

Product Number
    26225
    €2021
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    ₹ 388040.02
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$2,030.56

Thiol PEG carboxylic acid, Mp 10000

Product Number
    26224
    €2142
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$2,254.03

Thiol PEG carboxylic acid, Mp 5000

Product Number
    26223
    €2142
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$2,254.03

Thiol PEG carboxylic acid, Mp 3000

Product Number
    26222
    €2142
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$2,254.03

Thiol PEG Boc-hydrazine, Mp 10000

Product Number
    26221
    €2067
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    NT$ 104393
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    ₹ 415613.84
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$2,174.85
  • Facilitates PEGylation via primary amines, forming stable amide bonds.
  • Used for modifying proteins, peptides, and antibodies in therapeutic and diagnostic applications.
PEG NHS structure used in PEGylation via amide bonds

Click here to search our PEG-NHS products

Methoxy PEG NHS, Mp 5000

Product Number
    26066
    €263
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    NT$ 12240
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    ₹ 48730.50
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$255.00

NHS PEG Fmoc-amine alkyne, Mp 20000

Product Number
    26247
    €1568
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    NT$ 75570
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    ₹ 300864.02
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$1,574.38

NHS PEG Fmoc-amine alkyne, Mp 10000

Product Number
    26246
    €2646
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    NT$ 133673
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    ₹ 532186.75
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$2,784.86

NHS PEG Fmoc-amine alkyne, Mp 5000

Product Number
    26245
    €2646
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    NT$ 133673
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    ₹ 532186.75
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$2,784.86

NHS PEG Boc-amine alkyne, Mp 20000

Product Number
    26243
    €2646
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    NT$ 133673
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    ₹ 532186.75
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$2,784.86

NHS PEG Boc-amine alkyne, Mp 10000

Product Number
    26242
    €2646
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    NT$ 133673
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    ₹ 532186.75
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$2,784.86

NHS PEG Boc-amine alkyne, Mp 5000

Product Number
    26241
    €2646
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    NT$ 133673
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    ₹ 532186.75
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$2,784.86

NHS PEG Boc-amine alkyne, Mp 3000

Product Number
    26240
    €2370
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    NT$ 119720
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    ₹ 476637.80
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$2,494.18
  • Designed for covalent bonding to hydroxyl-rich surfaces like glass or silica.
  • Applications include anti-fouling coatings, biosensors, and drug delivery.
PEG Silane structure for bonding to glass and silica surfaces

Click here to search our PEG-Si products

Silane PEG Azide, Mp 20000

Product Number
    26235
    €2462
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    NT$ 124359
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    ₹ 495103.79
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$2,590.81

Silane PEG azide, Mp 10000

Product Number
    26234
    €2462
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    NT$ 124359
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    ₹ 495103.79
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$2,590.81

Silane PEG azide, Mp 5000

Product Number
    26233
    €2462
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    NT$ 124359
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    ₹ 495103.79
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$2,590.81

Silane PEG azide, Mp 3000

Product Number
    26232
    €2462
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    NT$ 124359
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    ₹ 495103.79
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$2,590.81

Silane PEG alkyne, Mp 20000

Product Number
    26231
    €2462
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    NT$ 124359
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    ₹ 495103.79
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$2,590.81

Silane PEG alkyne, Mp 10000

Product Number
    26230
    €2462
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    ₹ 495103.79
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$2,590.81

Silane PEG alkyne, Mp 5000

Product Number
    26229
    €1581
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    NT$ 75811
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    ₹ 301823.34
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$1,579.40

Silane PEG alkyne, Mp 3000

Product Number
    26228
    €2462
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    NT$ 124359
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    ₹ 495103.79
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$2,590.81

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Page References:

  • Fella, C., Walker, G. F., Ogris, M., & Wagner, E. (2008). Amine-reactive pyridylhydrazone-based PEG reagents for pH-reversible PEI polyplex shielding. European Journal of Pharmaceutical Sciences, 34(4-5), 309-320. https://doi.org/10.1016/j.ejps.2008.05.004
  • Ramirez-Paz, J., Saxena, M., Delinois, L. J., Joaquín-Ovalle, F. M., Lin, S., Chen, Z., ... & Griebenow, K. (2018). Thiol-maleimide poly (ethylene glycol) crosslinking of L-asparaginase subunits at recombinant cysteine residues introduced by mutagenesis. Plos one, 13(7), e0197643. https://doi.org/10.1371/journal.pone.0197643
  • Brady JD, T.; Lee PI; Li JX, Polymer Properties and Characterization, in: Qui YC, Y.; Zhang GGZ; Yu L; Mantri RV (Ed.) Developing Solid Oral Dosage Forms, Elsevier; 2017, pp. 181–223 Paper Excerpt PDF
  • Bjugstad, K. B., Redmond Jr, D. E., Lampe, K. J., Kern, D. S., Sladek Jr, J. R., & Mahoney, M. J. (2008). Biocompatibility of PEG-based hydrogels in primate brain. Cell transplantation, 17(4), 409-415. https://doi.org/10.3727/096368908784423292
  • Treetharnmathurot, B., Ovartlarnporn, C., Wungsintaweekul, J., Duncan, R., & Wiwattanapatapee, R. (2008). Effect of PEG molecular weight and linking chemistry on the biological activity and thermal stability of PEGylated trypsin. International journal of pharmaceutics, 357(1-2), 252-259. https://doi.org/10.1016/j.ijpharm.2008.01.016