PLA(1000)-b-PEG(10,000)-b-PLA(1000), Triblock Polymer

PLA-PEG-PLA triblock polymer is a biodegradable amphiphilic copolymer composed of poly(lactic acid) (PLA) blocks and a poly(ethylene glycol) (PEG) central segment. This structure provides a balance of hydrophilicity and hydrophobicity, making it ideal for biomedical and pharmaceutical applications. The PEG segment enhances solubility and biocompatibility, while the PLA blocks contribute to controlled degradation and mechanical strength. PLA-PEG-PLA is widely used in drug delivery, tissue engineering, and hydrogel formulations due to its biodegradability, low toxicity, and tunable physical properties.
Numbers in parentheses refer to approximate Mw of the segment.

Applications:

Drug Delivery: Forms biodegradable nanoparticles and micelles for controlled and sustained drug release in pharmaceutical formulations.

Tissue Engineering: Used as a biocompatible scaffold material for cell growth, supporting regenerative medicine applications.

Hydrogels & Injectable Systems: Enables thermo-responsive and pH-responsive hydrogel formation, making it useful in targeted drug delivery and wound healing applications.

3D Printing & Biofabrication: Acts as a printable biopolymer for scaffolds and medical implants, ensuring controlled degradation and high compatibility with biological environments.

Coatings & Surface Modification: Improves biocompatibility of medical devices and implants by reducing protein adsorption and enhancing surface hydrophilicity.