Amine PEG carboxylic acid hydrochloride, Mp 10000

Amine PEG Carboxylic Acid Hydrochloride (NH₂-PEG-COOH·HCl) is a heterobifunctional PEG with a primary amine (-NH₂) and a carboxyl (-COOH) group, supplied as a hydrochloride salt for increased stability. The amine end enables amide bond formation with NHS esters or isocyanates, while the carboxyl group allows conjugation via EDC/NHS coupling, making it ideal for bioconjugation, hydrogel crosslinking, and targeted drug delivery.

Applications:
Protein & Antibody Conjugation: Forms amide bonds with lysine residues in proteins for PEGylation.
Hydrogel Crosslinking: Used in carbodiimide-based crosslinking to improve hydrogel mechanics.
Surface Functionalization: Enhances biocompatibility of nanoparticles, implants, and biosensors.
Drug Delivery Systems: Provides functional handles for controlled drug release and nanoparticle conjugation.