Amine PEG tritylthiol, Mp 3000

Amine PEG Tritylthiol (NH₂-PEG-S-Trt) is a heterobifunctional PEG derivative containing a protected thiol (-S-Trt) and a reactive amine (-NH₂) group. The trityl (Trt) group protects the thiol from premature oxidation and can be selectively removed under mild acidic conditions to reveal a reactive thiol (-SH) for disulfide bonding or thiol-ene click chemistry. This design is highly useful for protein crosslinking, nanoparticle stabilization, and hydrogel crosslinking.

Applications:
Bioconjugation & Protein Crosslinking: Enables site-specific thiol conjugation in enzyme and antibody modifications.
Hydrogel & Polymer Networks: Allows thiol-mediated crosslinking for biodegradable scaffold formation.
Nanoparticle Functionalization: Forms disulfide-stabilized coatings for improved nanocarrier stability.
Surface Modification: Reacts with gold and silver surfaces for biosensor and implant coatings.