β-Sitosteryl hemisuccinate (β-STEMS)

β-Sitosteryl hemisuccinate (β-STEMS) is a β-sitosterol derivative that is responsive to changes in pH. β-sitosterol is a naturally occurring sterol lipid that is growing in the bioprocessing space for its ability to improve mRNA transfection efficiency. Conjugation to hemiscuccinate has been shown to improve the cellular uptake in acidic microenvironments, such as those around tumors.
SYNONYM: β-STEMS