FSL-1 is a synthetic lipopeptide used in immunology research as an agonist of the TLR2/TLR6 heterodimer. Also known as fibroblast-stimulating lipopeptide, FSL-1 is used to study innate immune response pathways and related toll-like receptor signaling workflows.
Related names: Fibroblast-stimulating lipopeptide, Pam2CGDPKHPKSF, (R,S)-Pam2Cys-Gly-Asp-Pro-Lys-His-Pro-Lys-Ser-Phe-OH, and S-[2,3-bis[(1-oxohexadecyl)oxy]propyl]-L-cysteinylglycyl-L-α-aspartyl-L-prolyl-L-lysyl-L-histidyl-L-prolyl-L-lysyl-L-seryl-L-phenylalanine.
This product has a molecular weight of 1666 g/mol and is supplied for laboratory research involving TLR2/TLR6 activation, innate immune signaling, and vaccine adjuvant research.
Key Properties
- Synthetic lipopeptide
- Product Number: 14709
- CAS Number: 322455-70-9
- Molecular weight: 1666 g/mol
- TLR2/TLR6 heterodimer agonist
- Application: vaccine adjuvant research
- Supplied sizes: 1 mg and 5 mg
- Store at -20°C
Applications
TLR2/TLR6 Signaling Research
FSL-1 is used in research workflows involving activation of the TLR2/TLR6 heterodimer and downstream innate immune signaling pathways.
Innate Immune Response Studies
As a synthetic lipopeptide agonist, FSL-1 is relevant to studies of toll-like receptor-mediated immune activation and cellular response to lipopeptide stimuli.
Vaccine Adjuvant Research
FSL-1 is used in vaccine adjuvant research where defined activation of innate immune signaling pathways is being evaluated.
Preparation & Compatibility Considerations
- Confirm reconstitution conditions, working concentration, and handling procedure before use
- Evaluate compatibility with the intended cell system, assay format, buffer, and experimental workflow
- Use appropriate controls when studying TLR2/TLR6-mediated signaling
- Refer to lot-specific documentation and the product SDS before preparing experimental materials
Experimental response may depend on cell type, receptor expression, concentration, exposure time, assay conditions, and control design.
Application Tips
- Use validated assay conditions for the intended TLR2/TLR6 workflow
- Include appropriate untreated, vehicle, and pathway-specific controls when applicable
- Prepare small-scale test conditions before routine experimental use
- Avoid making clinical, diagnostic, or therapeutic use assumptions without supporting documentation
Handling & Storage
- Store at -20°C
- Keep cool and store in a well-ventilated place
- Ensure good ventilation of the work area
- Wear appropriate personal protective equipment, including protective gloves and safety glasses
- Avoid release to the environment
- Follow the product SDS for complete handling, storage, cleanup, and disposal guidance
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FAQ
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1. What is FSL-1?
FSL-1 is a synthetic lipopeptide used in immunology research as an agonist of the TLR2/TLR6 heterodimer.
2. What does FSL-1 stand for?
FSL-1 is commonly referred to as fibroblast-stimulating lipopeptide. It is also known by the sequence name Pam2CGDPKHPKSF.
3. What is FSL-1 used for?
FSL-1 is used in research involving TLR2/TLR6 signaling, innate immune response studies, and vaccine adjuvant research.
4. What is the molecular weight of FSL-1?
FSL-1 has a molecular weight of 1666 g/mol.
5. How should FSL-1 be stored and handled?
Store FSL-1 at -20°C. Use appropriate laboratory precautions, including good ventilation, protective gloves, and safety glasses. Review the SDS before use for complete handling, storage, cleanup, and disposal guidance.
Safety & Documentation
Review the product specification and Safety Data Sheet before use. Handle with appropriate laboratory precautions, personal protective equipment, and ventilation. Follow SDS guidance for storage, cleanup, and disposal.
