PCL(10,000)-b-mPEG(4,000), Diblock polymer, Powder

PCL(10,000) - b - mPEG(4,000), Diblock polymer, Powder - Polysciences
PCL(10,000) - b - mPEG(4,000), Diblock polymer, Powder - Polysciences
Product Number:
50362

Size

Price

$327.54

Quantity

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Product Specifications
Linear Formula
    (C6H10O2)m[C2H4O]n 
Appearance
    White to off-white to light tan powder
Biodegradation Time
    Months to Years
Molecular Weight
    ~14,000
Synonyms
    mPEG-b-PCL
    mPEG-PCL
Safety Data Sheet (SDS)
Handling
    Gloves & fume hood
Storage
    Protect from moisture. Store at -20°C.
Hazards
    Harmless - use normal precautions; Hygroscopic
Related Documents

    No Related Documents

References

    1. Hou, Z., Zhou, W., Guo, X., Zhong, R., Wang, A., Li, J., ... & Tian, M. (2022). Poly (ε-Caprolactone)-Methoxypolyethylene Glycol (PCL-MPEG)-Based Micelles for Drug-Delivery: The Effect of PCL Chain Length on Blood Components, Phagocytosis, and Biodistribution. International Journal of Nanomedicine, 1613-1632.

    2. Luo, D., Wang, X., Zhong, X., Chang, J., He, M., Wang, H., ... & Ran, L. (2022). MPEG-PCL nanomicelles platform for synergistic metformin and chrysin delivery to breast cancer in mice. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 22(2), 280-293.

    3. Yin, W., Wang, Y., Xiao, Y., Mao, A., & Lang, M. (2022). Phenylboronic acid conjugated mPEG-b-PCL micelles as DOX carriers for enhanced drug encapsulation and controlled drug release. European Polymer Journal, 173, 111235.

    4. Erdemli, Ö., Usanmaz, A., Keskin, D., & Tezcaner, A. (2014). Characteristics and release profiles of MPEG-PCL-MPEG microspheres containing immunoglobulin G. Colloids and Surfaces B: Biointerfaces, 117, 487-496.

    5. Wang, T., Jiang, X. J., Tang, Q. Z., Li, X. Y., Lin, T., Wu, D. Q., ... & Okello, E. (2009). Bone marrow stem cells implantation with α-cyclodextrin/MPEG–PCL–MPEG hydrogel improves cardiac function after myocardial infarction. Acta biomaterialia, 5(8), 2939-2944.

Product Description

High-grade, suitable for biomedical research.
Supplied as micronized powder.

Polycaprolactone-b-polyethylene glycol Block Copolymer (PCL-b-mPEG) is a biodegradable and amphiphilic block copolymer that combines the hydrophobic polycaprolactone (PCL) with hydrophilic polyethylene glycol (PEG). The PCL segment offers slow degradation and hydrophobicity, while the PEG segment enhances water solubility and biocompatibility. This copolymer has excellent physical and chemical properties, including tunable molecular weight, adjustable degradation rates, and good solubility in organic solvents. The molecular weight and ratio of PCL to PEG can be tailored to specific application needs, allowing for flexibility in designing drug delivery systems, nanoparticles, and coatings. PCL-b-mPEG is highly suited for biomedical fields, particularly in drug delivery, tissue engineering, and hydrogels. The hydrophilic PEG segment provides steric stabilization for nanoparticles, improving circulation times and bioavailability in drug delivery applications. The slow degradation of PCL makes this copolymer ideal for controlled release systems. Furthermore, its biocompatibility and ease of processing make it an attractive material for use in scaffolds and implants in tissue engineering.
Synonyms/Acronyms:
mPEG-b-PCL mPEG-PCL
PCL(10,000) - b - mPEG(4,000), Diblock polymer, Powder - Polysciences
PCL(10,000) - b - mPEG(4,000), Diblock polymer, Powder - Polysciences
Product Specifications
Linear Formula
    (C6H10O2)m[C2H4O]n 
Appearance
    White to off-white to light tan powder
Biodegradation Time
    Months to Years
Molecular Weight
    ~14,000
Synonyms
    mPEG-b-PCL
    mPEG-PCL
Safety Data Sheet (SDS)
Handling
    Gloves & fume hood
Storage
    Protect from moisture. Store at -20°C.
Hazards
    Harmless - use normal precautions; Hygroscopic
Related Documents

    No Related Documents

References

    1. Hou, Z., Zhou, W., Guo, X., Zhong, R., Wang, A., Li, J., ... & Tian, M. (2022). Poly (ε-Caprolactone)-Methoxypolyethylene Glycol (PCL-MPEG)-Based Micelles for Drug-Delivery: The Effect of PCL Chain Length on Blood Components, Phagocytosis, and Biodistribution. International Journal of Nanomedicine, 1613-1632.

    2. Luo, D., Wang, X., Zhong, X., Chang, J., He, M., Wang, H., ... & Ran, L. (2022). MPEG-PCL nanomicelles platform for synergistic metformin and chrysin delivery to breast cancer in mice. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 22(2), 280-293.

    3. Yin, W., Wang, Y., Xiao, Y., Mao, A., & Lang, M. (2022). Phenylboronic acid conjugated mPEG-b-PCL micelles as DOX carriers for enhanced drug encapsulation and controlled drug release. European Polymer Journal, 173, 111235.

    4. Erdemli, Ö., Usanmaz, A., Keskin, D., & Tezcaner, A. (2014). Characteristics and release profiles of MPEG-PCL-MPEG microspheres containing immunoglobulin G. Colloids and Surfaces B: Biointerfaces, 117, 487-496.

    5. Wang, T., Jiang, X. J., Tang, Q. Z., Li, X. Y., Lin, T., Wu, D. Q., ... & Okello, E. (2009). Bone marrow stem cells implantation with α-cyclodextrin/MPEG–PCL–MPEG hydrogel improves cardiac function after myocardial infarction. Acta biomaterialia, 5(8), 2939-2944.