PEG di(OPSS), Mp 2000

PEG Di(OPSS) (OPSS-PEG-OPSS) is a bifunctional PEG derivative featuring ortho-pyridyl disulfide (OPSS) groups at both ends. These groups form disulfide bonds with thiol-containing molecules, enabling reversible conjugation and redox-responsive drug delivery applications. The OPSS moiety is particularly useful for thiol-mediated crosslinking in protein conjugation, nanoparticle stabilization, and hydrogel formation.

Applications:
Protein & Peptide Conjugation: Forms reversible disulfide linkages with thiol-containing biomolecules.
Stimuli-Responsive Hydrogels: Enables redox-sensitive crosslinking for drug delivery systems.
Nanoparticle Functionalization: Provides biocompatible coatings for thiol-reactive nanoparticles.
Biointerface Engineering: Enhances stability and functionality of biosensors and medical coatings.