PLA(10,000)-b-mPEG(1,500), Diblock polymer, Powder

Product Number:

50359

Size

Price

$327.54

Quantity

Bulk Request

Request a Bulk Quote

Product Specifications

Spec_50359

Linear Formula

(C3H4O2)m[C2H4O]n

Appearance

White to off-white to light tan powder

Biodegradation Time

Months to Years

Molecular Weight

~11,500

Synonyms

Safety Data Sheet (SDS)

SDS_50359.pdf

Handling

Gloves & fume hood

Storage

Protect from moisture. Store at -20°C.

Hazards

Harmless - use normal precautions; Hygroscopic

Related Documents

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References

1. Shi, X., Si, W., Zhu, J., & Zhang, S. (2024). Boosting the Electrical Performance of PLA‐Based Triboelectric Nanogenerators for Sustainable Power Sources and Self‐Powered Sensing. Small, 20(15), 2307620.

2. Kumbham, S., Paul, M., Bhatt, H., Ghosh, B., & Biswas, S. (2020). Oleanolic acid-conjugated poly (D, L-lactide)-based micelles for effective delivery of doxorubicin and combination chemotherapy in oral cancer. Journal of Molecular Liquids, 320, 114389.

3. Ghasemi, R., Abdollahi, M., Emamgholi Zadeh, E., Khodabakhshi, K., Badeli, A., Bagheri, H., & Hosseinkhani, S. (2018). mPEG-PLA and PLA-PEG-PLA nanoparticles as new carriers for delivery of recombinant human Growth Hormone (rhGH). Scientific reports, 8(1), 9854.

4. Panahi, F. H., Peighambardoust, S. J., Davaran, S., & Salehi, R. (2017). Development and characterization of PLA-mPEG copolymer containing iron nanoparticle-coated carbon nanotubes for controlled delivery of Docetaxel. Polymer, 117, 117-131.

5. Zhang, Q. Z., Zha, L. S., Zhang, Y., Jiang, W. M., Lu, W., Shi, Z. Q., ... & Fu, S. K. (2006). The brain targeting efficiency following nasally applied MPEG-PLA nanoparticles in rats. Journal of drug targeting, 14(5), 281-290.

Product Description

High-grade, suitable for biomedical research.
Supplied as micronized powder.

(Polylactic Acid-b-polyethylene glycol) (PLA-b-mPEG) is a biodegradable block copolymer combining polylactic acid (PLA), a hydrophobic polyester, with polyethylene glycol (PEG), a hydrophilic polymer. This amphiphilic copolymer offers a balance between hydrophobicity and hydrophilicity, making it suitable for drug delivery, tissue engineering, and biomedical applications. PLA provides biodegradability and mechanical strength, while the PEG component enhances water solubility and biocompatibility. The molecular weight of each segment can be customized, offering flexibility in tuning properties such as degradation rate, hydrophobic/hydrophilic balance, and mechanical properties.

PLA-b-mPEG is commonly used in controlled drug delivery systems, especially for hydrophobic drugs, where the PLA segment provides a controlled degradation profile and the PEG segment enhances solubility and stability. It is also used in creating hydrogels, nanoparticles, and micelles, facilitating applications in cancer therapy, wound healing, and implantable devices. PLA--bmPEG's biocompatibility and biodegradability make it a material of choice for developing temporary implants and scaffolds in tissue engineering.

Synonyms/Acronyms:

PLA-b-mPEG PLA-mPEG