PLA(50,000)-b-mPEG(4,000), Diblock polymer, Powder

Product Number:

    50356

Size

Price

$318.00

Quantity

Request a Bulk Quote 

Product Specifications

    Spec-50356

Safety Data Sheet (SDS)
Related Documents

    No Related Documents

References

    1. Shi, X., Si, W., Zhu, J., & Zhang, S. (2024). Boosting the Electrical Performance of PLA‐Based Triboelectric Nanogenerators for Sustainable Power Sources and Self‐Powered Sensing. Small, 20(15), 2307620.

    2. Kumbham, S., Paul, M., Bhatt, H., Ghosh, B., & Biswas, S. (2020). Oleanolic acid-conjugated poly (D, L-lactide)-based micelles for effective delivery of doxorubicin and combination chemotherapy in oral cancer. Journal of Molecular Liquids, 320, 114389.

    3. Ghasemi, R., Abdollahi, M., Emamgholi Zadeh, E., Khodabakhshi, K., Badeli, A., Bagheri, H., & Hosseinkhani, S. (2018). mPEG-PLA and PLA-PEG-PLA nanoparticles as new carriers for delivery of recombinant human Growth Hormone (rhGH). Scientific reports, 8(1), 9854.

    4. Panahi, F. H., Peighambardoust, S. J., Davaran, S., & Salehi, R. (2017). Development and characterization of PLA-mPEG copolymer containing iron nanoparticle-coated carbon nanotubes for controlled delivery of Docetaxel. Polymer, 117, 117-131.

    5. Zhang, Q. Z., Zha, L. S., Zhang, Y., Jiang, W. M., Lu, W., Shi, Z. Q., ... & Fu, S. K. (2006). The brain targeting efficiency following nasally applied MPEG-PLA nanoparticles in rats. Journal of drug targeting, 14(5), 281-290.

PLA(50,000) - b - mPEG(4,000), Diblock polymer, Powder - Polysciences
PLA(50,000) - b - mPEG(4,000), Diblock polymer, Powder - Polysciences

Product Description

High-grade, suitable for biomedical research.
Supplied as micronized powder.

(Polylactic Acid-b-polyethylene glycol) (PLA-b-mPEG) is a biodegradable block copolymer combining polylactic acid (PLA), a hydrophobic polyester, with polyethylene glycol (PEG), a hydrophilic polymer. This amphiphilic copolymer offers a balance between hydrophobicity and hydrophilicity, making it suitable for drug delivery, tissue engineering, and biomedical applications. PLA provides biodegradability and mechanical strength, while the PEG component enhances water solubility and biocompatibility. The molecular weight of each segment can be customized, offering flexibility in tuning properties such as degradation rate, hydrophobic/hydrophilic balance, and mechanical properties.

PLA-b-mPEG is commonly used in controlled drug delivery systems, especially for hydrophobic drugs, where the PLA segment provides a controlled degradation profile and the PEG segment enhances solubility and stability. It is also used in creating hydrogels, nanoparticles, and micelles, facilitating applications in cancer therapy, wound healing, and implantable devices. PLA--bmPEG's biocompatibility and biodegradability make it a material of choice for developing temporary implants and scaffolds in tissue engineering.
Synonyms/Acronyms:
PLA-b-mPEG PLA-mPEG
PLA(50,000) - b - mPEG(4,000), Diblock polymer, Powder - Polysciences
PLA(50,000) - b - mPEG(4,000), Diblock polymer, Powder - Polysciences
Product Specifications

    Spec-50356

Linear Formula
    (C3H4O2)m[C2H4O]n 
Appearance
    White to off-white to light tan powder
Biodegradation Time
    Months to Years
Safety Data Sheet (SDS)
Handling
    Gloves & fume hood
Storage
    Protect from moisture. Store at -20°C.
Hazards
    Harmless - use normal precautions; Hygroscopic
Related Documents

    No Related Documents

References

    1. Shi, X., Si, W., Zhu, J., & Zhang, S. (2024). Boosting the Electrical Performance of PLA‐Based Triboelectric Nanogenerators for Sustainable Power Sources and Self‐Powered Sensing. Small, 20(15), 2307620.

    2. Kumbham, S., Paul, M., Bhatt, H., Ghosh, B., & Biswas, S. (2020). Oleanolic acid-conjugated poly (D, L-lactide)-based micelles for effective delivery of doxorubicin and combination chemotherapy in oral cancer. Journal of Molecular Liquids, 320, 114389.

    3. Ghasemi, R., Abdollahi, M., Emamgholi Zadeh, E., Khodabakhshi, K., Badeli, A., Bagheri, H., & Hosseinkhani, S. (2018). mPEG-PLA and PLA-PEG-PLA nanoparticles as new carriers for delivery of recombinant human Growth Hormone (rhGH). Scientific reports, 8(1), 9854.

    4. Panahi, F. H., Peighambardoust, S. J., Davaran, S., & Salehi, R. (2017). Development and characterization of PLA-mPEG copolymer containing iron nanoparticle-coated carbon nanotubes for controlled delivery of Docetaxel. Polymer, 117, 117-131.

    5. Zhang, Q. Z., Zha, L. S., Zhang, Y., Jiang, W. M., Lu, W., Shi, Z. Q., ... & Fu, S. K. (2006). The brain targeting efficiency following nasally applied MPEG-PLA nanoparticles in rats. Journal of drug targeting, 14(5), 281-290.