PLGA(50:50)(50,000)-b-mPEG (4,000), Diblock polymer, Powder

High-grade, suitable for biomedical research.
Supplied as micronized powder.
(Poly(lactic-co-glycolic acid)-b-polyethylene glycol) (PLGA-b-mPEG) is a biodegradable and amphiphilic block copolymer composed of poly(lactic-co-glycolic acid) (PLGA), a widely used biodegradable polymer, and polyethylene glycol (PEG), known for its hydrophilic and biocompatible properties. The copolymer combines the controlled degradation of PLGA with the solubilizing and biocompatibility-enhancing effects of PEG. The ratio of lactic acid to glycolic acid in the PLGA segment, as well as the molecular weight of both PLGA and PEG, can be tailored to modulate degradation rates, mechanical properties, and hydrophilic-lipophilic balance.
This copolymer finds extensive use in drug delivery systems, especially in creating nanoparticles, micelles, and hydrogels, where its amphiphilic nature allows for effective encapsulation and controlled release of hydrophobic drugs. The PEG component increases water solubility and minimizes protein adsorption, improving circulation time and reducing immune system recognition. PLGA-b-mPEG is particularly advantageous in applications such as cancer therapeutics, tissue engineering, and bioactive scaffolds, where it enables tunable degradation and biocompatibility for implantable devices. Its versatility makes it a favored material for developing advanced biomedical applications requiring precise control over material properties and drug delivery kinetics.