Poly(D,L-lactide-co-glycolide), 75:25, IV 0.8 dL/g, ester terminated, is a biodegradable PLGA copolymer supplied as micronized powder for biomedical materials research, polymer formulation studies, and controlled-release development. This 75:25 D,L-lactide:glycolide grade is commonly used in research involving biodegradable matrices, microspheres, nanoparticles, films, scaffolds, and solvent-processed polymer systems.
Synonyms and related names: PLGA; poly(D,L-lactide-co-glycolide); D,L-lactide & glycolide copolymer; poly(lactic-co-glycolic acid).
This ester-terminated PLGA grade is useful when lactide:glycolide ratio, viscosity grade, end-group chemistry, and powder form are important formulation variables. Compared with lower-viscosity PLGA grades, a higher IV grade may be selected for research where polymer chain length, mechanical behavior, degradation profile, or release performance are being evaluated.
Final suitability should be confirmed under the user’s specific formulation, processing, and end-use conditions.
Key Properties
- Biodegradable PLGA copolymer
- 75:25 D,L-lactide:glycolide ratio
- Ester-terminated polymer
- IV 0.8 dL/g viscosity grade
- Supplied as micronized powder
- Solvent-processable in compatible organic solvents
- Designed for research and formulation development workflows
Applications
Controlled-Release Research
PLGA 75:25 IV 0.8 may be used in controlled-release formulation research where polymer composition, viscosity grade, end-group chemistry, and solvent processing influence release behavior.
Microsphere & Nanoparticle Development
This PLGA grade is useful for research involving polymeric microspheres, nanoparticles, and biodegradable carrier systems prepared through solvent-based processing methods.
Biomedical Materials Research
PLGA is widely studied for biodegradable films, scaffolds, coatings, and matrices used in biomedical materials research and prototype development.
3D Printing & Scaffold Studies
The polymer may be evaluated in research workflows involving biodegradable scaffold concepts, printable polymer systems, and structure-property studies.
Polymer Formulation & Compatibility Testing
This material can be used to screen PLGA compatibility with solvents, additives, active compounds, processing conditions, and formulation variables before scale-up.
Solubility & Compatibility
- Soluble in chloroform, acetone, ethyl acetate, and tetrahydrofuran
- Useful for solvent-based PLGA solution preparation
- Compatible processing conditions depend on solvent system, polymer concentration, mixing time, and temperature
- End-use performance depends on polymer ratio, viscosity grade, end-group chemistry, geometry, and formulation components
- Evaluate compatibility and release behavior under intended experimental conditions
PLGA solution behavior, particle formation, film quality, and degradation profile can vary with solvent choice, concentration, water exposure, residual solvent removal, and processing method.
Preparation Tips
- Use dry, clean, solvent-compatible glassware and equipment
- Dissolve in a listed compatible organic solvent under appropriate ventilation
- Add polymer gradually with mixing to support uniform wetting and dissolution
- Protect the polymer from moisture during weighing and transfer
- Allow the sealed container to equilibrate before opening to reduce condensation risk
- Filter, degas, or dry prepared solutions as required by the application
- Perform small-scale compatibility testing before preparing larger batches
- Confirm lot-specific values with the Certificate of Analysis when required
Handling & Storage
- Store at -20°C
- Protect from moisture
- Keep container tightly closed when not in use
- Material is listed as hygroscopic
- Use gloves and handle in a fume hood
- Follow normal laboratory precautions
- Review available product documentation before use
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FAQ
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1. What is PLGA 75:25 IV 0.8 ester terminated used for?
It is used in biodegradable polymer research, controlled-release formulation studies, microsphere and nanoparticle development, biomedical materials research, and solvent-processed film or scaffold preparation.
2. What does the 75:25 ratio mean?
The 75:25 ratio refers to the lactide:glycolide composition of the PLGA copolymer.
3. What does IV 0.8 dL/g mean?
IV 0.8 dL/g identifies the viscosity grade of this PLGA and helps researchers select a polymer grade for formulation and processing studies.
4. What does ester terminated mean?
Ester terminated refers to the polymer end-group chemistry. End-group selection can influence polymer behavior in formulation, degradation, and controlled-release research.
5. What solvents can dissolve this PLGA grade?
This product is listed as soluble in chloroform, acetone, ethyl acetate, and tetrahydrofuran.
6. How should this PLGA powder be stored?
Store at -20°C and protect from moisture. Keep the container tightly closed, minimize moisture exposure during handling, and use gloves and a fume hood.
Safety & Documentation
Review the product specification and available documentation before use. This hygroscopic PLGA powder should be stored at -20°C, protected from moisture, and handled with gloves in a fume hood using normal laboratory precautions. Confirm lot-specific test results with the Certificate of Analysis when required for application-specific or regulated workflows.
