Thiol PEG Boc-hydrazine, Mp 5000

Thiol-PEG-Boc-Hydrazine is a bifunctional PEG linker with a thiol (-SH) group for metal or thiol-based conjugation and a Boc-protected hydrazine (-NH-NH₂) that enables selective aldehyde coupling after deprotection. The PEG backbone enhances aqueous solubility and reduces protein interactions, making it ideal for bioconjugation, drug delivery, and hydrogel chemistry. Its unique hydrazine functionality allows for dynamic and reversible Schiff base chemistry, useful in applications requiring controlled release or self-healing properties.

Applications:
Bioconjugation: Enables site-specific aldehyde coupling after Boc deprotection for controlled biomolecule attachment.
Drug Delivery: Facilitates hydrazone-sensitive drug payload attachment for pH-responsive controlled release systems.
Surface Modification: Functionalizes biomaterials with hydrazine groups for selective aldehyde-mediated conjugation.
Hydrogels & Polymer Networks: Provides reversible crosslinking for self-healing and degradable hydrogel structures with tunable release profiles.