Thiol PEG carboxylic acid, Mp 5000

Thiol-PEG-Carboxylic Acid is a bifunctional PEG derivative featuring a thiol (-SH) group for stable attachment to gold, silver, and thiol-reactive surfaces, along with a carboxyl (-COOH) group for EDC/NHS-mediated amide coupling. This hydrophilic linker enhances biocompatibility, prevents nonspecific interactions, and enables precise conjugation strategies. Its dual functionality makes it highly useful in biofunctional surface coatings, nanoparticle stabilization, and hydrogel-based biomaterial development.

Applications:
Bioconjugation: Enables covalent attachment to proteins and peptides through amide bond formation for biomedical and diagnostic applications.
Surface Functionalization: Creates carboxyl-terminated coatings on metal and polymer substrates for biosensors, implants, and medical coatings.
Nanoparticle Stabilization: Functionalizes gold, silver, and polymeric nanoparticles for enhanced dispersion, bioactivity, and targeting.
Hydrogels & Polymer Networks: Facilitates crosslinking and biofunctionalization in hydrogel matrices for cell scaffolding, drug delivery, and regenerative medicine.