THS PEG OPSS, Mp 5000

THS-PEG-OPSS is a thiol-reactive polyethylene glycol (PEG) derivative featuring an orthopyridyl disulfide (OPSS) end group, which enables efficient and reversible thiol-thiol exchange reactions for stable disulfide bond formation. The PEG backbone enhances aqueous solubility, minimizes nonspecific interactions, and improves biocompatibility. This versatile linker is widely used in biomolecular conjugation, surface modification, and nanomaterial stabilization, making it ideal for applications requiring thiol-based reactivity in biomedical and material sciences.

Applications:
Bioconjugation & Drug Delivery: Links thiol-containing biomolecules via disulfide bonds, enabling controlled drug release and targeted bioconjugation strategies.
Surface Functionalization: Modifies gold, glass, and polymeric surfaces with reactive disulfide groups for biosensors and diagnostic platforms.
Nanoparticle Stabilization: Prevents aggregation and improves dispersion of gold, silver, and quantum dot nanoparticles for biomedical imaging and therapeutic delivery.
Hydrogels & Polymer Networks: Integrates into hydrogel systems to introduce thiol-based crosslinking sites for tunable degradability and biofunctionalization.