Tritythiol PEG NHS, Mp 5000

Tritylthiol-PEG-NHS is a thiol-protected PEG linker with an N-hydroxysuccinimide (NHS) ester for rapid amine coupling. The trityl group protects the thiol (-SH) from oxidation, allowing controlled deprotection for sequential functionalization. Its PEG backbone enhances solubility, reduces protein fouling, and improves bioavailability, making it ideal for dual-stage conjugation strategies in biomaterials, drug delivery, and surface modification.

Applications:
Bioconjugation: Enables site-selective amine coupling before controlled thiol activation for multi-step conjugation strategies in biomolecule attachment.
Surface Modification: Creates dual-reactive coatings on biomaterials for sequential ligand functionalization in biosensing and biointerface engineering.
Nanoparticle Functionalization: Facilitates stepwise bioconjugation of nanoparticles for improved targeting, stability, and bioavailability in drug delivery and imaging.
Hydrogels & Polymer Networks: Supports controlled thiol activation in hydrogel formulations, enabling sequential crosslinking and functionalization for responsive biomaterials.