Poly(D,L-lactide-co-glycolide) (PLGA), 75:25, IV 0.65 dL/g, is a biodegradable aliphatic polyester with a nominal 75:25 molar ratio of lactide-derived to glycolide-derived units. It is a lactide-rich PLGA copolymer for laboratory material evaluation and formulation development.
Grade selection requires consideration of copolymer composition, viscosity measurement conditions, end-group chemistry, molecular-weight distribution, and residual monomer content. The nominal IV of 0.65 dL/g does not independently establish molecular weight or predict formulation performance.
PLGA undergoes hydrolytic cleavage of its ester backbone. Comparative studies of 75:25 and 50:50 PLGA films found slower degradation for the 75:25 composition under the conditions tested. That comparison does not establish a degradation or release timeline for this grade.
Key Properties
- Product number: 25107
- CAS number: 26780-50-7
- Copolymer composition: Nominal 75:25 molar ratio of D,L-lactide-derived to glycolide-derived units
- Nominal IV: 0.65 dL/g
- Physical form: Solid
- Polymer class: Biodegradable aliphatic polyester
- Soluble in chloroform, DMSO, dichloromethane, acetone, ethyl acetate, and tetrahydrofuran
- Abbreviations: PLGA; PDLGA; DL-PLGA
Applications
Controlled-Release Formulation Research
PLGA polymers are used as matrices in drug-loaded particle formulations. Encapsulation and release behavior depend on polymer characteristics, payload properties, and preparation method. Results obtained with another PLGA grade or formulation do not establish the performance of this material.
Polymer Film Research
PLGA 75:25 films have been used to investigate relationships between copolymer composition, specimen thickness, and hydrolytic degradation. Processing history and film geometry should be controlled when comparing molecular-weight reduction, mass loss, and morphological changes.
Comparative Degradation Studies
Comparisons of PLGA 75:25 and PLGA 50:50 can help investigate composition-dependent degradation behavior. Molecular-weight reduction and polymer mass loss are distinct measurements: chain cleavage can occur before substantial material is lost from the specimen.
Composition & Processing Considerations
- The 75:25 ratio describes lactide:glycolide composition, independently of the IV designation
- Compare IV values using the same viscosity definition, solvent, temperature, and polymer concentration
- Use molecular-weight characterization when selection depends on molecular weight or molecular-weight distribution
- Evaluate dissolution at the intended polymer concentration, temperature, and solvent composition
- Confirm end-group chemistry and critical material specifications before transferring a formulation between PLGA grades
Storage & Product Selection
- Store the solid polymer at −20°C, protected from moisture
- Package sizes: 1 g and 5 g
- Package catalog numbers: 25107-1 and 25107-5
- Handle with appropriate ventilation, protective gloves, safety glasses, and protective clothing
- Download the SDS for PLGA 75:25, IV 0.65 dL/g
- For larger quantities or custom PLGA requirements, contact Polysciences and specify catalog 25107 or your target composition, IV or molecular-weight requirements, end groups, physical form, quantity, and documentation needs
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FAQ
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1. What does PLGA 75:25 mean?
PLGA stands for poly(lactide-co-glycolide). For this poly(D,L-lactide-co-glycolide) grade, 75:25 describes the nominal molar ratio of lactide-derived to glycolide-derived units. In LA:GA notation, lactide is the first component and glycolide is the second.
2. What does IV 0.65 dL/g mean?
This grade has a nominal IV of 0.65 dL/g; dL/g means deciliters per gram. Interpretation requires the viscosity definition and measurement conditions. Intrinsic and inherent viscosity are different quantities and should not be used interchangeably when comparing specifications.
3. How does PLGA 75:25 differ from PLGA 50:50?
PLGA 75:25 contains a higher proportion of lactide-derived units. Comparative film studies found slower degradation for 75:25 than for 50:50 under the conditions tested. When comparing it with PLGA 50:50, IV 0.6 dL/g, also evaluate viscosity measurement conditions, end groups, molecular-weight distribution, and processing history.
4. How quickly does PLGA 75:25, IV 0.65 dL/g degrade?
A fixed degradation time cannot be assigned from composition and nominal IV alone. Temperature, pH, specimen dimensions, processing history, end groups, and formulation affect hydrolysis and mass loss. Drug release is a separate outcome influenced by diffusion and interactions within the polymer matrix.
5. Can I discuss custom PLGA specifications with Polysciences?
Yes. Contact Polysciences to discuss composition, viscosity, end-group chemistry, physical form, packaging, and scale. Share the intended application and critical material attributes so the team can assess development options and documentation requirements.
6. Is this PLGA grade available as GMP-grade material?
No. This catalog PLGA is intended for research use, and GMP-grade PLGA is not currently available. For programs with clinical or commercial requirements, contact Polysciences to discuss material specifications, available documentation, and development requirements before selecting a grade.
7. How should this PLGA be stored, and where can I obtain the SDS?
Store the solid polymer at −20°C, protected from moisture. Download the Safety Data Sheet for PLGA 75:25, IV 0.65 dL/g, catalog 25107. These storage instructions apply to the polymer and do not establish stability conditions for prepared solutions or formulations.
